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Maternal Basic Fibroblast Growth Factor Serum Levels Are Associated With Pregnancy-Induced Hypertension

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Abstract

Objective

TO test the hypothesis that serum levels of basic fibroblast growth f actor (bFGF) are altered among women with pregnancy-induced hypertension (PIH) and are associated with disease severity.

Methods

We evaluated serum levels of bFGF in 46 women with PIH, 46 age- and parity-matched healthy pregnant women, and 46 healthy nonpregnant controls. Enzyme-linked immunosorbent assays were used to determine serum levels of bFGF. Results were correlated to clinical data.

Results

The overall mean serum levels of bFGF were 3.2 (standard deviation [SD] 9.3) μmol/L. Mean serum levels of bFGF in normal controls, healthy pregnant women, and women with PIH were 0 (SD 0) μmol/L, 2.6 (SD 6.3) μmol/L, and 6.8 (SD 13.8) μmol/L, respectively (P = .003) for normal controls compared with healthy pregnant women and P < .001 for healthy pregnant women compared with women with PIH). In a univariate logistic regression model bFGF showed a significant influence on the odds of presenting with PIH compared with healthy pregnant women (P = .002). The mean serum levels of bFGF in women with severe PIH and in women with mild PIH were 4.4 (SD 10.6) μmol/L and 9.5 (SD 17.3) μmol/L, respectively (P = .1). In a univariate logistic regression model bFGF did not reveal a significant influence on the odds of developing severe PIH (P = .3).

Conclusions

Elevated serum levels of bFGF are associated with PIH, but bFGF does not seem to be a useful prognostic parameter for severe PIH.

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, University of Vienna Medical School, A-1090, Währinger Gürtel 18-20, Vienna, Austria

    Christine Kurz MD, Lukas Hefler MD, Harald Zeisler MD, Christian Schatten MD, Peter Husslein MD & Clemens Tempfer MD

  2. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA

    Christine Kurz MD, Lukas Hefler MD, Harald Zeisler MD, Christian Schatten MD, Peter Husslein MD & Clemens Tempfer MD

Authors
  1. Christine Kurz MD
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  2. Lukas Hefler MD
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  3. Harald Zeisler MD
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  4. Christian Schatten MD
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  5. Peter Husslein MD
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  6. Clemens Tempfer MD
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Corresponding author

Correspondence to Clemens Tempfer MD.

Additional information

The authors thank Ingrid Schiebel for expert technical assistance.

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Kurz, C., Hefler, L., Zeisler, H. et al. Maternal Basic Fibroblast Growth Factor Serum Levels Are Associated With Pregnancy-Induced Hypertension. Reprod. Sci. 8, 24–26 (2001). https://doi.org/10.1177/107155760100800104

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  • DOI: https://doi.org/10.1177/107155760100800104

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