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Magnesium Sulfate and Fetal Plasma Concentrations of Epinephrine, Norepinephrine, and Vasopressin in Response to Acute Hypoxemia in Goats

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Abstract

Objective

We measured fetal plasma concentrations of epinephrine, norepinephrine, and vasopressin during acute hypoxemia in goats and tested whether hypermagnesemia altered these endocrine responses.

Methods

Five chronically catheterized goat fetuses at 124–129 days’ gestation were used. After 4 hours of infusion (magnesium or vehicle as controls), 30 minutes of hypoxemia was induced by infusing nitrogen gas through a maternal tracheal catheter. Fetal plasma concentrations of epinephrine, norepinephrine, and vasopressin were measured before and during hypoxemia. Both magnesium sulfate and vehicle infusions were performed in each animal. Repeated-measures analysis of variance (ANOA) and two-way ANOVA with post hoc test were used to determine statistical significance.

Results

During hypoxemia, fetal Po2 decreased significantly from 30 to 14 mmHg with no significant changes in fetal pH or Pco2 in both groups. Fetal heart rate was reduced significantly by hypoxemia, but to a lesser extent in the magnesium group (change in decrease in fetal heart rate: 41 beats per minute [bp] in controls versus 26 bpm with magnesium). Mean blood pressure did not change significantly during hypoxemia in both groups. Fetal plasma concentrations of epinephrine, norepinephine, and vasopressin significantly increased from the prehypoxemic values both with magnesium and in controls. There were no significant differences in these hormone concentrations between magnesium and the controls.

Conclusion

Magnesium sulfate had no effect on fetal plasma concentrations of vasopressin, epinephrine, and norepinephrine during acute hypoxemia.

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Authors and Affiliations

  1. Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan

    Hiroshi Sameshima MD, PhD, Shigeki Tanaka MD, Masato Kamitomo MD, Tsuyomu Ikenoue MD & Hiroshi Sakamoto MD, DVM

  2. Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan

    Hiroshi Sameshima MD, PhD, Shigeki Tanaka MD, Masato Kamitomo MD, Tsuyomu Ikenoue MD & Hiroshi Sakamoto MD, DVM

  3. Department of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

    Hiroshi Sameshima MD, PhD, Shigeki Tanaka MD, Masato Kamitomo MD, Tsuyomu Ikenoue MD & Hiroshi Sakamoto MD, DVM

Authors
  1. Hiroshi Sameshima MD, PhD
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  2. Shigeki Tanaka MD
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  3. Masato Kamitomo MD
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  4. Tsuyomu Ikenoue MD
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  5. Hiroshi Sakamoto MD, DVM
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Corresponding author

Correspondence to Hiroshi Sameshima MD, PhD.

Additional information

Supported by grant 9-B-1 from the Ministry of Health and Welfare, Japan, and grant 09671700 from the Ministry of Education, Science, Sports, and Culture, Japan.

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Sameshima, H., Tanaka, S., Kamitomo, M. et al. Magnesium Sulfate and Fetal Plasma Concentrations of Epinephrine, Norepinephrine, and Vasopressin in Response to Acute Hypoxemia in Goats. Reprod. Sci. 7, 328–332 (2000). https://doi.org/10.1177/107155760000700602

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