Abstract
Randomly assigning patients is considered the choice in clinical trials when comparing different treatments. Automatic treatment assignment systems have been developed in order to reduce costs, increase reliability, or to provide 24-hour service. Communication devices such as telephone, telefax, and computers can be used for this purpose. Advantages and disadvantages of the different technologies are discussed. It is demonstrated that the newly proposed central treatment assignment via standard computer networks is feasible, comfortable, and efficient.
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References
Pocock SJ. Allocation of patients to treatment in clinical trials. Biometrics. 1979;35(1): 183–197.
Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics. 1975;31(1):103–115.
Krischer JP, Hurley C, Pillalamarri M, Pant S, Bleichfeld C, Opel M, Shuster JJ. An automated patient registration and treatment randomization system for multicenter clinical trials. Control Clin Trials. 1991; 12(3):367–377.
Pello JY. An automated vocal system for patient registration and randomization management. App Clin Trials. 1992;1(8):26–29.
Akazawa K, Kamakura T, Sakamoto M, Odaka T, Nose Y. Patient registration and treatment allocation in multicenter clinical trials using a FAX-OCR system. Meth Inf Med. 1994;33(5):530–534.
Lange N, MacIntyre J. A computerized patient registration and treatment randomization system for multi-institutional clinical trials. Control Clin Trials. 1985; 6(1):38–50.
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Haag, U. Technologies for Automating Randomized Treatment Assignment in Clinical Trials. Ther Innov Regul Sci 32, 7–11 (1998). https://doi.org/10.1177/009286159803200102
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DOI: https://doi.org/10.1177/009286159803200102