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The objectives of this study were to benchmark patient recruitment and retention practices across recently completed global clinical trials from a working group of biopharmaceutical companies. The data collection focused on recruitment and retention tactics used by companies as well as detailed information about the size and scope of the global trials conducted. In-depth organizational information regarding patient recruitment and retention structure and functions was collected. Despite numerous tactics available, participating companies indicated using a small number of patient recruitment and retention tactics. In addition, companies reported that 32% of studies did not implement any tactics. Traditional tactics were most widely used, including physician referrals (16%), newspaper advertisements (16%), and radio advertisements (13%). The relationship between use of recruitment tactics and enrollment data was explored and a positive association was found between use of nontraditional recruitment tactics and enrollment rates.

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  1. Lovato L, Hill K, Hertert S, Hunninghake D, Probstfield J. Recruitment for controlled clinical trials: literature summary and annotated bibliography. Control Clin Trials. 1997;18:328–352.

    Article  CAS  Google Scholar 

  2. Sung N, Crowley W, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289:1278–1287.

    Article  Google Scholar 

  3. Glass H. What bothers clinical investigators? Informa UK. Published July 2009.

  4. Getz K, Wenger J. Assessing the impact of protocol design change on clinical trial performance. Am J Ther. 2008;15:449–456.

    Google Scholar 

  5. Lai G, Gary T, Tilburt J, et al. Effectiveness of strategies to recruit underrepresented populations into cancer clinical trials. Clin Trials. 2006;3(2):133–141.

    Article  Google Scholar 

  6. McAnulty J. Bringing patient recruitment into our digital world. Drug Inf J. 2009;43:501–508.

    Article  Google Scholar 

  7. Li G. Site activation: the key to more efficient clinical trials., Advanstar Communication. December 12, 2008.

  8. Thomaselli R. FDA’s social-media “guidelines” befuddle big pharma. Accessed December 30, 2011.

Download references

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Correspondence to Mary Jo Lamberti PhD.

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Lamberti, M.J., Mathias, A., Myles, J.E. et al. Evaluating the Impact of Patient Recruitment and Retention Practices. Ther Innov Regul Sci 46, 573–580 (2012).

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