Reproductive Sciences

, Volume 19, Issue 5, pp 547–554 | Cite as

Single-Nucleotide Polymorphisms in the KDR Gene in Pregnancies Complicated by Gestational Hypertensive Disorders and Small-for-Gestational-Age Infants

  • Prabha H. Andraweera
  • Gustaaf A. Dekker
  • Steven D. Thompson
  • Claire T. RobertsEmail author
Original Articles



Pregnancies complicated by preeclampsia and small-for-gestational-age (SGA) infants share placental vascular abnormalities and both disorders confer increased risk of later life coronary artery disease. Kinase insert domain receptor (KDR) is the main receptor for vascular endothelial growth factor A, a potent angiogenic factor which regulates the development of the placental vasculature. Two polymorphisms in KDR (-604T/C and Val297Ile) are known to be associated with coronary artery disease. We investigated the association of these polymorphisms with preeclampsia, gestational hypertension, and SGA infants.


Nulliparous pregnant women, their partners, and infants were recruited to a prospective cohort study (n = 1169). Doppler ultrasound of the uterine and umbilical arteries was performed at 20 weeks of gestation. Preeclampsia, gestational hypertension, and SGA were defined according to international guidelines. DNA extracted from peripheral venous or cord blood was genotyped using the Sequenom MassARRAY system. Multivariable logistic regression was used to compare the odds for the pregnancy complications between the genotype groups adjusting for potential confounders.


Among 937 Caucasian pregnancies, 427 (45.6%) were uncomplicated, 75 (8.0%) developed preeclampsia, 102 (10.9%) developed gestational hypertension, and 72 (7.7%) had SGA infants in the absence of maternal hypertensive disease. Paternal and neonatal KDR-604T/C was associated with preeclampsia (adjusted odds ratio [aOR] 1.6, 95% confidence interval [CI] 1.0–3.0 and aOR 2.2, 95% CI 1.0–4.4), SGA (aOR 1.9, 95% CI 1.1–3.3 and aOR 2.2, 95% CI 1.2–3.9), and SGA with abnormal Doppler (aOR 2.7, 95% CI 1.2–5.9 and aOR 3.2, 95% CI 1.2–5.9).


Paternal and neonatal carriage of the KDR-604T/C polymorphism is associated with the risk of preeclampsia and SGA infants.


KDR polymorphism preeclampsia small-for-gestational-age infants 


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Copyright information

© Society for Reproductive Investigation 2012

Authors and Affiliations

  • Prabha H. Andraweera
    • 1
    • 2
  • Gustaaf A. Dekker
    • 1
    • 3
  • Steven D. Thompson
    • 1
  • Claire T. Roberts
    • 1
    Email author
  1. 1.Discipline of Obstetrics and Gynaecology, Robinson InstituteUniversity of AdelaideAustralia
  2. 2.Human Genetics Unit, Faculty of MedicineUniversity of ColomboSri Lanka
  3. 3.Women’s and Children’s DivisionLyell McEwin Hospital, Elizabeth ValeSouth Australia

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