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Solute Carrier Family 19, Member 1 (SLC19A1) Polymorphisms (−43T>C, 80G>A, and 696C>T), and Haplotypes in Idiopathic Recurrent Spontaneous Abortion in a Korean Population

Abstract

The objective was to investigate the association between idiopathic recurrent spontaneous abortion (RSA) and 3 SLC19A1 polymorphisms (−43T>C, 80G>A, and 696C>T). DNA from 269 patients with RSA and 125 controls were genotyped for the 3 SLC19A1 single nucleotide polymorphisms (SNPs) by polymerase chain reaction–restriction fragment length polymorphism. Homocysteine and folate levels of 100 patients with RSA were available for analysis. The combination genotypes of SLC19A1 −43TC/80GG, −43TC/80AA, and −43CC/80GA; 80GA/696TT, 80AA/696CC; and −43TC/696CC were less frequent in patients with RSA compared to controls (P < .05 for each). The −43C/80A/696 T and −43T/80G/696C haplotypes were more frequent in patients than controls, whereas −43T/80A/696C, −43C/80A/696C, −43C/80G/696C, −43C/80G/696T, and −43T/80G/696T haplotypes were less frequent in patients (P < .05 for each). The −43T/80G and 80A/696T haplotypes were more frequent in patients, while −43T/80A, −43C/80G, 80A/696C, 80G/696T, and −43C/696C haplotypes occurred less frequently in patients (P < .05 for each). The associations between idiopathic RSA occurrence and SLC19A1 −43T>C/80G>A/696C>T polymorphisms were identified and can be developed as biomarkers for RSA risk.

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Correspondence to Sung Han Shim PhD or Nam Keun Kim PhD.

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Rah, H., Choi, Y.S., Jeon, Y.J. et al. Solute Carrier Family 19, Member 1 (SLC19A1) Polymorphisms (−43T>C, 80G>A, and 696C>T), and Haplotypes in Idiopathic Recurrent Spontaneous Abortion in a Korean Population. Reprod. Sci. 19, 513–519 (2012) doi:10.1177/1933719111426604

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Keywords

  • recurrent spontaneous abortion
  • homocysteine
  • folate
  • SLC19A1
  • single nucleotide polymorphism