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Brain Natriuretic Peptide in Term Pregnancy

Abstract

Objective

To determine the normal range of serum brain natriuretic peptide (BNP) in uncomplicated, singleton term pregnant patients.

Study Design

Serum for analysis of BNP was drawn at admission to labor and delivery (= 104), prior to administration of intravenous fluid.

Results

Median BNP was 20 pg/mL, with an interquartile range of 20 pg/mL (range 5–70 pg/mL; or a mean ± standard deviation [SD] of 23 ± 16 pg/mL). Brain natriuretic peptide negatively correlated with prepregnant (r = −.24, P < .05) and pregnant weight (r = −26, P < .01) and with heart rate (r = −.35, P < 0.001); heart rate was also positively correlated with BMI (r = .32). Brain natriuretic peptide levels were higher in Hispanic than African American women, independent of body mass index (BMI) and heart rate.

Conclusions

Brain natriuretic peptide values found in term pregnant patients are similar to those of prepregnant women of reproductive age. Brain natriuretic peptide levels appear to be set by conditions present in the prepregnant condition and maintained, despite changes in plasma volume, systemic vascular resistance, and cardiac output.

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Correspondence to Ladin Yurteri-Kaplan MD.

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Yurteri-Kaplan, L., Saber, S., Zamudio, S. et al. Brain Natriuretic Peptide in Term Pregnancy. Reprod. Sci. 19, 520–525 (2012) doi:10.1177/1933719111426598

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Keywords

  • body mass index
  • brain natriuretic peptide
  • pregnancy