Reproductive Sciences

, Volume 19, Issue 1, pp 70–80 | Cite as

Aqueous Fenugreek Seed Extract Ameliorates Adriamycin-Induced Cytotoxicity and Testicular Alterations in Albino Rats

  • Saber A. SakrEmail author
  • Salama M. El-shenawy
  • Ahmed M. Al-Shabka
Original Articles


The present work studied the effect of fenugreek seed extracts on cytotoxicity and testicular damage induced by adriamycin (ADR) in albino rats. Administrating animals with ADR caused significant increase in the percentage of chromosomal aberrations, decreased the mitotic index, and induced DNA damage in bone marrow. Testes of ADR-treated rats showed many histopathological alterations and the number of sperm head abnormalities increased. Moreover, the concentration of malondialdehyde (MDA) increased and the activity of catalase (CAT) and superoxide dismutase (SOD) decreased in the testis. Treating animals with ADR and aqueous seed extracts of fenugreek led to an improvement in the cytogenetic effect and testicular alterations induced by ADR. Lipid peroxidation was reduced and the activities of CAT and SOD were increased. In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.


adriamycin fenugreek chromosomal aberrations testis antioxidants 


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Copyright information

© Society for Reproductive Investigation 2012

Authors and Affiliations

  • Saber A. Sakr
    • 1
    Email author
  • Salama M. El-shenawy
    • 2
  • Ahmed M. Al-Shabka
    • 1
  1. 1.Department of Zoology, Faculty of ScienceMenoufia UniversityShibin el-KomEgypt
  2. 2.Laboratory Department, Teaching HospitalMenoufia UniversityShebin el-KomEgypt

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