Reproductive Sciences

, Volume 19, Issue 1, pp 64–69 | Cite as

Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis

  • Liqing Chen
  • Ruijia Fan
  • Xiufeng Huang
  • Hong Xu
  • Xinmei ZhangEmail author
Original Articles


The authors previously demonstrated decreased levels of pigment epithelium-derived factor (PEDF) in peritoneal fluid of women with endometriosis compared to women without endometriosis. Here, the authors determine whether women with endometriosis have altered levels of PEDF in serum. Peripheral blood samples were collected from 71 women with and without endometriosis (n = 43 and 28, respectively) before laparoscopic surgery. Concentrations of serum PEDF were measured by enzyme-linked immunosorbent assay. We detected lower levels of serum PEDF in women with endometriosis (16.3 ± 6.6 ng/mL) than in those without endometriosis (24.5 ± 7.3 ng/mL; P < .001). In women with endometriosis, the concentrations of serum PEDF were significantly lower in women with pain (n = 11, 12.6 ± 7.1 ng/mL) compared to women without pain (n = 32, 17.5 ± 6.0 ng/mL; P < .05). However, the concentrations of serum PEDF did not correlate with disease stage or site or infertility. In addition, the concentrations of serum PEDF did not show any difference in the phase of the cycle in either group. Our results suggest that reduced levels of serum PEDF in women with endometriosis and disease-related pain may play a role in the pathogenesis of this disease.


endometriosis serum angiogenesis pigment epithelium-derived factor 


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Copyright information

© Society for Reproductive Investigation 2012

Authors and Affiliations

  • Liqing Chen
    • 1
  • Ruijia Fan
    • 1
  • Xiufeng Huang
    • 1
  • Hong Xu
    • 1
  • Xinmei Zhang
    • 1
    Email author
  1. 1.Women’s Hospital, Zhejiang University School of MedicineHangzhou, ZhejiangP. R. China

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