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Reproductive Sciences

, Volume 18, Issue 12, pp 1246–1252 | Cite as

Multiparity Causes Uncoordinated Activity of Pelvic- and Perineal-Striated Muscles and Urodynamic Changes in Rabbits

  • Margarita Martínez-GómezEmail author
  • Germán Mendoza-Martínez
  • Dora Luz Corona-Quintanilla
  • Víctor Fajardo
  • Jorge Rodríguez-Antolín
  • Francisco Castelán
Original Articles

Abstract

Temporal and coordinated activation of pelvic- (pubococcygeous) and perineal- (bulbospongiosus and ischiocavernosus) striated muscles occurs during micturition in female rabbits. We have hypothesized that the coordinated activation of pelvic and perineal muscles is modified during the micturition of young multiparous rabbits. Young virgin and multiparous female chinchilla rabbits were used to simultaneously record cystometrograms and electromyograms of the pubococcygeous, ischocavernosus, and bulbospongiosus muscles. Bladder function was assessed using standard urodynamic variables. The temporal coordination of pelvic- and perineal-striated muscle activity was changed in multiparous rabbits. The cystometrogram recordings were different than those obtained from virgin rabbits, as seen in alterations of the threshold volume, the residual volume, the voiding duration, and the maximum pressure. In rabbits, we find that multiparity causes uncoordinated activity of pubococcygeous, ischiocavernosus, and bulbospongiosus muscles and modifies the urodynamics.

Keywords

multiparity micturition striated musculature pelvic floor perineum 

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Copyright information

© Society for Reproductive Investigation 2011

Authors and Affiliations

  • Margarita Martínez-Gómez
    • 1
    • 2
    • 5
    Email author
  • Germán Mendoza-Martínez
    • 3
  • Dora Luz Corona-Quintanilla
    • 2
  • Víctor Fajardo
    • 4
  • Jorge Rodríguez-Antolín
    • 2
  • Francisco Castelán
    • 1
    • 2
  1. 1.Depto. de Biología Celular y Fisiología, Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de México (UNAM)MéxicoMéxico
  2. 2.Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de Tlaxcala (UATx)TlaxcalaMéxico
  3. 3.Maestría en Ciencias Biológicas, UATxTlaxcalaMéxico
  4. 4.Fac. de CienciasUniversidad Autónoma del Estado de MéxicoTolucaMéxico
  5. 5.Instituto de Investigaciones Biomédicas, Unidad Periférica Tlaxcala-UNAMUniversidad Autónoma de TlaxcalaTlaxcalaMéxico

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