Reproductive Sciences

, Volume 18, Issue 4, pp 398–405 | Cite as

Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on β1- and β2-Adrenergic Receptors in the Fetal Baboon Liver

  • Amrita KamatEmail author
  • Mark J. Nijland
  • Thomas J. McDonald
  • Laura A. Cox
  • Peter W. Nathanielsz
  • Cun Li
Original Articles


Hepatic β-adrenergic receptors (β-ARs) play a pivotal role in mobilization of reserves via gluconeogenesis and glycogenolysis to supply the animal with its energy needs during decreased nutrient availability. Using a unique nutrient-deprived baboon model, we have demonstrated for the first time that immunoreactive hepatic β1- and β2-AR subtypes are regionally distributed and localized on cells around the central lobular vein in 0.5 and 0.9 gestation (G) fetuses of ad libitum fed control (CTR) and maternal nutrient restricted (MNR) mothers. Furthermore, MNR decreased fetal liver immunoreactive β1-AR and increased immunoreactive β2-AR at 0.5G. However, at 0.9G, immunohistochemistry and Western blot analysis revealed a decrease in β1-AR and no change in β2-AR levels. Thus, MNR in a nonhuman primate species has effects on hepatic β1- and β2-ARs that are receptor- and gestation stage-specific and may represent compensatory systems whose effects would increase glucose availability in the presence of nutrient deprivation.


β-adrenergic receptor immunolocalization gene expression protein expression baboon 


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Copyright information

© Society for Reproductive Investigation 2011

Authors and Affiliations

  • Amrita Kamat
    • 1
    • 2
    Email author
  • Mark J. Nijland
    • 3
    • 5
  • Thomas J. McDonald
    • 3
    • 4
  • Laura A. Cox
    • 4
    • 5
  • Peter W. Nathanielsz
    • 3
    • 4
  • Cun Li
    • 3
    • 4
  1. 1.Department of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Geriatric Research, Education and Clinical Center, Audie L. Murphy DivisionSouth Texas Veterans Health Care SystemSan AntonioUSA
  3. 3.Center for Pregnancy and Newborn ResearchUniversity of Texas Health Science CenterSan AntonioUSA
  4. 4.Department of GeneticsSouthwest Foundation for Biomedical ResearchSan AntonioUSA
  5. 5.Southwest National Primate Research CenterSouthwest Foundation for Biomedical ResearchSan AntonioUSA

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