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What if Derek Willoughby were right? Cyclo-oxygenase is an anti-inflammatory enzyme

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References

  • Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. and Markowska, A. L. (2001). Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice, J. Neurosci. 21, 8198–8209.

    PubMed  CAS  Google Scholar 

  • Bodamyali, T., Stevens, C. R., Billingham, M. E., Ohta, S. and Blake, D. R. (1998). Influence of hypoxia in inflammatory synovitis (Review), Ann. Rheum. Dis. 57, 703–710.

    Article  PubMed  CAS  Google Scholar 

  • Cuzzocrea, S., Wayman, N. S., Mazzon, E., Dugo, L., Di Paola, R., Serraino, I., Britti, D., Chatterjee, P. K., Caputi, A. P. and Thiemermann, C. (2002). The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 attenuates the development of acute and chronic inflammation, Mol. Pharmacol. 61, 997–1007.

    Article  PubMed  CAS  Google Scholar 

  • Dieppe, P. A., Ebrahim, S., Martin, R. M. and Juni, P. (2004). Lessons from the withdrawal of rofecoxib, Br. Med. J. 329, 867–868.

    Article  Google Scholar 

  • DuBois, R. N. (1999). COX-2 in large bowel cancer: a one-sided story, Gut 45, 636–637.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, J., Mukherjee, R., Munro, A. F., Wells, A. C., Almushatat, A. and Bartlett, J. M. (2004). HER2 and COX-2 expression in human prostate cancer, Eur. J. Cancer 40, 50–55.

    Article  PubMed  CAS  Google Scholar 

  • Egan, K. M., Lawson, J. A., Fries, S., Koller, B., Rader, D. J., Smyth, E. M. and Fitzgerald, G. A. (2004). COX-2 derived prostacyclin confers atheroprotection on female mice, Science 306, 1954–1957.

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald, G. A. (2004). Coxibs and cardiovascular disease, N. Engl. J. Med. 351, 1709–1711.

    Article  PubMed  CAS  Google Scholar 

  • Gilroy, D. W., Colville-Nash, P. R., Willis, D., Chivers, J., Paul-Clark, M. J. and Willoughby, D. A. (1999). Inducible cyclooxygenase may have anti-inflammatory properties, Nature Med. 5, 698–701.

    Article  PubMed  CAS  Google Scholar 

  • Goodson, N. J., Wiles, N. J., Lunt, M., Barrett, E., Silman, A. J. and Symmons, D. P. M. (2002). Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients, Arthritis Rheum. 46, 2010–2019.

    Article  PubMed  Google Scholar 

  • Li, L., Tao, J., Davaille, J., Feral, C., Mallat, A., Rieusset, J., Vidal, H. and Lotersztajn, S. J. (2001). 15-deoxy-Delta-12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors, Biol. Chem. 276, 38152–38158.

    CAS  Google Scholar 

  • Pruthi, R. S. and Derksen, E. (2004). A phase II trial of celecoxib in PSA recurrent prostate cancer after definitive radiation therapy or radical prostatectomy, J. Clin. Oncol. 22(Suppl.), 4593 (Abstract).

    Google Scholar 

  • Pignatelli, M., Sanchez-Rodriguez, J., Santos, A. and Perez-Castillo, A. (2005). 15-deoxy-Δ-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism, Carcinogenesis 26, in press.

  • Schonbeck, U., Sukhova, G. K., Graber, P., Coulter, S. and Libby, P. (1999). Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions, Am. J. Pathol. 155, 1281–1291.

    PubMed  CAS  Google Scholar 

  • VIOXX Information Centre (2004). Accessible at http://www.merck.com

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Blake, D.R., Shenker, N., Cohen, H. et al. What if Derek Willoughby were right? Cyclo-oxygenase is an anti-inflammatory enzyme. Inflammopharmacol 12, 465–471 (2005). https://doi.org/10.1163/156856005774382742

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  • DOI: https://doi.org/10.1163/156856005774382742

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