An infectious/inflammatory process plays a role in at least a subgroup of patients with tics and Tourette’s syndrome (TS). Successful antibiotic therapy and prophylaxis was described repeatedly. We report the case of a patient suffering from chronic TS who was treated with celecoxib additionally to the antibiotic prophylaxis. This treatment was associated with a continous improvement of tics and disturbed behaviour, such as aggression and social withdrawal. The withdrawal of celecoxib led to a marked deterioration in TS symptoms while the re-exposition had advantageous therapeutic effects. This result of the treatment with a COX-2 inhibitor supports the view that COX-2 inhibitors show therapeutic benefit in patients suffering from psychiatric disorders in which an inflammatory process is involved in the pathophysiology.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Müller, N. Anti-inflammatory therapy with a COX-2 inhibitor in Tourette’s syndrome. Inflammopharmacology 12, 271–275 (2004). https://doi.org/10.1163/1568560042342338
Published:
Issue Date:
DOI: https://doi.org/10.1163/1568560042342338