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Biochemical aspects and functional role of the copper-containing amine oxidases

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Abstract

The copper-containing amine oxidases of the class EC 1.4.3.6 share many biochemical similarities. They contain cupric copper and catalyse the same general reaction. In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines. However, the functional role of benzylamine oxidase (BAO) and the tissue semicarbazide-sensitive amine oxidases (SSAO) is still under investigation. Circulating BAO is derived from the tissue SSAO. It has a high affinity for benzylamine and its role in the extra-cellular matrix includes the maturation of pro-elastin and control of the inflammatory process.

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  1. Department of Pharmacology, University of Florence, Florence, Italy

    F. Buffoni

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  1. F. Buffoni
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  2. G. Ignesti
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Buffoni, F., Ignesti, G. Biochemical aspects and functional role of the copper-containing amine oxidases. Inflammopharmacology 11, 203–209 (2003). https://doi.org/10.1163/156856003322315550

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