Abstract
Multiple organ dysfunction syndrome, including acute respiratory distress syndrome (ARDS) and renal failure, is described, its clinical features outlined, its origins in tissue oxidative stress following severe infections, surgical trauma, ionizing radiation, high-dosage drugs and chemicals, severe hemorrhage, etc., are defined, and its prevention and treatment prescribed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Asherson, R. A. (1992). The catastrophic antiphospholid syndrome, J. Rheumatol. 19, 508–512.
el-Barbary, M. and Khabar, K. S. (2002). Soluble tumor necrosis factor receptor p55 predicts cytokinemia and systemic inflammatory response after cardiopulmonary bypass, Crit. Care Med. 30, 1712–1716.
Bone, R. C., Balk, R. A., Cerra, F. B., et al. (1992). Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, Chest 101, 1644–1655.
Brealey, D. and Singer, M. (2000a). Multi-organ dysfunction in critically ill: epidemiology, patho-physiology and management, J. R. Coll. Phys. Lond. 34, 424–427.
Brealey, D. and Singer, M. (2000b). Multi-organ dysfunction in the critically ill: effects on different organs, J. R. Coll. Phys. Lond. 34, 428–431.
Brealey, D., Brand, M., Hargreaves, I., et al. (2002). Association between mitochondrial dysfunction and severity and outcome of septic shock, Lancet 360, 219–223.
Cabioglu, N., Bilgic, S., Deniz, G., et al. (2002). Decreased cytokine expression in peripheral blood leukocytes of patients with severe sepsis, Arch. Surg. 137, 1037–1043.
Clermont, G., Angus, D. C., Linde-Zwirble, W. T., et al. (2002). Does acute organ dysfunction predict patient-centred outcomes, Chest 121, 1963–1971.
Curran, C. A. (2002). Multiple organ dysfunction syndrome (MODS) in the obstetric population, J. Perinat. Neonat. Nurs. 15, 37–55.
Deodhar, S. D. (1982). Autoimmune diseases: Overview and current concepts of pathogenesis, Clin. Biochem. 25, 181–185.
Gando, S., Kameue, T., Morimoto, Y., et al. (2002). Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis, Crit. Care Med. 30, 1729–1734.
Gharavi, A. E. (2001). The anticardiolipin syndrome: antiphospholipid syndrome, Clin. Med. J. R. Coll. Phys. Lond. 1, 14–17.
Grant, A. (2002). Leukocytes and neurogenic inflammation, Inflammopharmacology 9, 403–420.
Green, J. and Lynn, W. A. (2000). Septicaemia: Presentation and clinical features of severe sepsis, J. R. Coll. Phys. Lond. 34, 418–423.
Halonen, K. I., Pettilä, V., Leppaniemi, A. K., et al. (2002). Multiple organ dysfunction associated with severe acute pancreatitis, Crit. Care Med. 30, 1274–1279.
Ihle, B. U. and Oziemski, P. (2002). Multi-organ failure secondary to catastrophic anti-phospholipid syndrome, Anaesth. Intensive Care 30, 82–85.
Jankowski, S., MacLachlan, K., Stephenson. J., et al. (2002). Necrotising infections and group G streptococcus, Lancet 359, 2277.
Kern, J. W. and Shoemaker, W. C. (2002). Meta-analysis of haemodynamic optimization in high-risk patients, Crit. Care Med. 30, 1686–1692.
Lee, H. A., Gabriel, R. and Bolton. J. P. G. (2002). Health status and clinical diagnoses of 3000 UK Gulf War veterans, J. R. Soc. Med. 95, 491–497.
Liu, P. T., Kentish, P. A., Symons, A. M., et al. (1993a). The effects of ether anaesthesia on Oxidative stress in ratsdose response, Toxicology 80, 37–49.
Liu, P. T., Ioannides, C., Symons, A. M., et al. (1993b). Role of tissue glutathione in prevention of surgical trauma, Xenobiotica 23, 899–911.
Liu, P. T., Symons, A. M., Howarth, J. A., et al. (1994). Studies in surgical trauma: oxidative stress in ischaemia-reperfusionof rat liver, Clin. Sci. 86, 453–460.
Liu, P. T., Baohaun, J., Quilley, J., et al. (2000). Peroxynitrite attenuates hepatic ischaemia-reperfusion injury, Am. J. Physiol. 279, C1970–C1977.
Meduri, G. V., Headley, A. S., Golden, E., et al. (1998). Effect of prolonged methylprednisolone therapy in unresolved respiratory distress syndrome: a randomized controlled trial, J. Am. Med. Ass. 280, 159–165.
Moore, F. A., Savania, A., Moore, E. E., et al. (1996). Post injury multiple organ failure: A bimodel pheonenom, J. Trauma 40, 501–512.
Nast-Kolb, D., Waydhas, C., Gippner-Steppert, C., et al. (1997). Indicators of the prost traumatic inflammatory response correlate with organ failure in patients with multiple injuries, J. Trauma 42, 446–453.
Panaphut, T., Domrongkitchaiporn, S. and Thinkamrop, B. (2002). Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand, Int. J. Infect. Dis. 6, 52–59.
Pettilä, V., Pettilä, M., Sarna, S., et al. (2002). Comparison of multiple organ dysfunction scores in the prediction of hospital mortality in the critically ill, Crit. Care Med. 30, 1705–1711.
Ronco, C., Ricci, Z. and Bellomo, R. (2002). Importance of increased ultrafiltration volume and impact on mortality: sepsis and cytokine story and the role for CVVH, EDTNA ERCA J. 13, 8.
Rook, G. and Zumla, A. (1997). Gulf War Syndrome, Is it due to a systemic shift in cytokine balance towards a Th2 profile?, Lancet 349, 1831–1833.
Sheng, Z. (2002). Prevention of multiple organ dysfunction syndrome in patients with extensive deep burns, Chin. J. Traumatol. 5, 195–199.
The Acute Respiratory Distress Syndrome Network (2000). Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome, N. Engl. J. Med. 342, 1301–1308.
Wessely, S. and the King's College Gulf War Research Unit (2001). Ten years on: What do we know about the Gulf War Syndrome?, Clin. Med. J. R. Coll. Phys. Lond. 1, 28–37.
Wood, L., Miller, D., Jacobs, P., et al. (2002). Trypanosomiasis — an unusual cause of reversible multiple organ dysfunction in South Africa, S. Afr. Med. J. 92, 527–528.
Rights and permissions
About this article
Cite this article
Parke, A.L., Liu, P.T. & Parke, D.V. Multiple organ dysfunction syndrome. Inflammopharmacology 11, 87–95 (2003). https://doi.org/10.1163/156856003321547130
Issue Date:
DOI: https://doi.org/10.1163/156856003321547130