Research on Chemical Intermediates

, Volume 19, Issue 7, pp 657–668 | Cite as

Antioxidant activity of lipophilic vitamin c derivative in dipalmitoyl phosphatidylcholine vesicles — A stopped-flow esr kinetic study

  • L. -M. Wu
  • F. -L. Guo
  • Z. -L. Liu
  • Y. -L. Zhang
  • X. -Q. Jia
  • Y. -C. Liu
Article

Abstract

The antioxidant reactivity of the lipophilic derivative of vitamin C, i.e., ascorbyl-6-palmitate (VC-16) was remarkably enhanced in dipalmitoyl phosphatidylcholine (DPPC) vesicles. The rate enhancement is tentatively explained by a vesicle fusion mechanism and subsequent lateral diffusion of reactants within the vesicle. The reduction of nitroxides incorporated into the vesicle by VCs was employed to examine the distribution of the nitroxide inside and outside the vesicle as well as the dynamic behaviour of the inside-outside transition (flip-flop).

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Copyright information

© Springer 1993

Authors and Affiliations

  • L. -M. Wu
    • 1
  • F. -L. Guo
    • 1
  • Z. -L. Liu
    • 1
  • Y. -L. Zhang
    • 1
  • X. -Q. Jia
    • 1
  • Y. -C. Liu
    • 1
  1. 1.National Laboratory of Applied Organic Chemistry and Department of ChemistryLanzhou UniversityGansuChina

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