Research on Chemical Intermediates

, Volume 30, Issue 9, pp 889–901 | Cite as

Enantio-differentiating hydrogenation of methyl acetoacetate over modified nickel catalysts: effects of nickel dispersion on the enantio-selectivity of catalysts

  • Donghyun Jo
  • Jae Sung Lee
  • Kyung Hee Lee
Article

Enantio-differentiating hydrogenation of methyl acetoacetate was performed over the supported nickel catalysts modified by the solution of (R,R)-tartaric acid or (S)-malic acid and NaBr. The reduction temperature of supported nickel was the most important factor determining the enantio-selectivity of catalysts. The reduction temperature changed the nickel dispersion, by which the quantity and coverage of modifier adsorption were varied. The enantio-selectivity of modifiers both (R,R)-tartaric acid and (S) -malic acid were compared at various reduction temperatures. (R,R)-tartaric acid with two hydroxyl groups in a molecule showed an optimum coverage on the nickel surface that gave the maximum ee value. The maximum ee value was 72% at the reduction temperature of 973 K. In contrast, (S)-malic acid with one hydroxyl group in a molecule showed a monotonous decrease in ee and decreasing amounts of adsorbed modifier with increasing reduction temperatures.

ENANTIO-DIFFERENTIATING HYDROGENATION TARTARIC ACID MALIC ACID METHYL ACETOACETATE 

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© VSP 2004

Authors and Affiliations

  • Donghyun Jo
  • Jae Sung Lee
  • Kyung Hee Lee

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