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Knowing As Making, Making As Knowing: The Many Lives of Synthetic Biology

Abstract

The ways in which the various activities of synthetic biology connect to those of conventional biology display both a multiplicity and variety that reflect the multiplicity and variety of meanings for which the term synthetic biology has been invoked, today as in the past. Central to this variety, as well as to the connection itself, is the complex relationship between knowing (understanding, representing) and making (constructing, intervening) that has prevailed in the life sciences. That relationship is the focus of this article. More specifically, my aim is to explore the different assumptions about how knowing is related to making that have prevailed, implicitly or explicitly in the various activities—now or in the past—subsumed under the name synthetic biology.

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References

  • Bensaude-Vincent B (2008) Technoscience and convergence: A transmutation of values? Available at http://www.ethicschool.eu

  • Boncheva M, Gracias DH, Jacobs HO, Whitesides GM (2002) Biomimetic self-assembly of a functional asymmetrical electronic device. Proceedings of the National Academy of Sciences of the USA 99: 4937–4940.

    Article  Google Scholar 

  • Collingwood RG ([1940] 1998) An Essay on Metaphysics. Oxford: Clarendon. Rev. ed., Oxford: Oxford University Press.

    Google Scholar 

  • Greenfield D, McEvoy AL, Shroff H, Crooks GE, Wingreen NS, Betzig E, Liphardt J (2009) Self-Organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy. PLoS Biology 7(6): e1000137. doi:10.1371/journal.pbio.1000137

    Article  Google Scholar 

  • Hacking I (1983) Representing and Intervening: Introductory Topics in the Philosophy of Natural Science. Cambridge, UK: Cambridge University Press.

    Book  Google Scholar 

  • Keller EF (1996) The biological gaze. In: Future Natural (Robertson G, Mash M, Tickner L, Bird J, Curtis B, Putnam T, eds), 107–121. London: Routledge.

    Google Scholar 

  • Keller EF (2002) Making Sense of Life. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Keller EF (2009) What does synthetic biology have to do with biology? BioSocieties 4: 275–286.

    Article  Google Scholar 

  • Leduc S (1910) Théorie Physico-Chimique de la Vie et Générations Spontanées. Paris: A. Poinat.

    Google Scholar 

  • Leduc S (1911) The Mechanism of Life (Butcher WD, trans). New York: Rebman Co.; London: Heinemann.

    Google Scholar 

  • Leduc S (1912) La Biologie Synthétique, Etude de Biophysique. Paris: A. Poinat.

    Google Scholar 

  • Loeb J (1912) The Mechanistic Conception of Life. Chicago, IL: University of Chicago Press.

    Book  Google Scholar 

  • Pauly PJ (1987) Controlling Life: Jacques Loeb and the Engineering Ideal in Biology. Oxford: Oxford University Press.

    Google Scholar 

  • Turing AM (1952) The chemical basis of morphogenesis. Philosophical Transactions of the Royal Society of London B237: 37–72.

    Article  Google Scholar 

  • Weinberg, RA (1985) The molecules of life. Scientific American 253(4): 4857.

    Article  Google Scholar 

  • Wilson EB (1900) Aspects of recent biological research. International Monthly 2: 86–88.

    Google Scholar 

  • Woodward J (2003) Making Things Happen: A Theory of Causal Explanation. Oxford: Oxford University Press.

    Google Scholar 

  • Yim M, Shen W-M, Salemi B, Rus D, Moll M, Lipson H, Klavins E, Chirikjian GS (2007) Modular self-reconfigurable robot systems, 2007. Robotics and Automation Magazine, IEEE 14(1): 43–52.

    Article  Google Scholar 

  • Yin P, Choi HMT, Calvert CR, Pierce NA (2008) Programming biomolecular self-assembly pathways. Nature 451: 318–322.

    Article  Google Scholar 

Download references

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Correspondence to Evelyn Fox Keller.

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This article grew out of a previous one (Keller in press) that was also based on a lecture given at the École Normale Sup érieure (Paris, March 17, 2009). The particular argument being made here, however, is somewhat different, even if it does draw on many of the same quotations for support.

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Keller, E.F. Knowing As Making, Making As Knowing: The Many Lives of Synthetic Biology. Biol Theory 4, 333–339 (2009). https://doi.org/10.1162/BIOT_a_00005

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  • DOI: https://doi.org/10.1162/BIOT_a_00005

Keywords

  • efficiency
  • engineering
  • material models
  • practical cause
  • synthetic biology
  • technoscience
  • theoretical models
  • understanding