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The European Physical Journal Special Topics

, Volume 226, Issue 5, pp 889–904 | Cite as

Study of the molecular mobility of (±)-methocarbamol in the amorphous solid state

Regular Article
Part of the following topical collections:
  1. Phase Equilibria and Their Applications

Abstract

The experimental techniques of differential scanning calorimetry (DSC) and thermally stimulated depolarization currents (TSDC) were used to study the thermal behavior of the pharmaceutical drug (±)-methocarbamol and its slow molecular mobility (in the 10−3–10−2 Hz range) in the amorphous solid state. The possibility of polymorphism was considered based on the DSC results. The glass forming ability and the glass stability were investigated by DSC, and the general kinetic features of the main relaxation, including the fragility or steepness index, were studied by both experimental techniques. The secondary relaxations detected by TSDC revealed fast and slow (Johari-Goldstein) modes. These secondary relaxations of different nature were assigned based on physical aging studies.

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© EDP Sciences and Springer 2017

Authors and Affiliations

  1. 1.CQFM – Centro de Química-Física Molecular and IN – Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de LisboaLisboaPortugal
  2. 2.CQE – Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de LisboaLisboaPortugal

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