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Humerus absorbed dose in breast cancer postoperative radiotherapy. Simulation with FOTELP-VOX code and comparison with treatment planning system

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Abstract

Determining the dose of scattered radiation absorbed by specific body organs and tissues in radiotherapy is very important. In this study, we chose the humerus to determine the absorbed dose in female breast cancer patients who have undergone postoperative radiotherapy. In addition to direct dosimetry, another way to determine the absorbed dose to an identified organ of the human body is the FOTELP-VOX simulation. Selected five patients were treated at the Centre for Radiation Oncology, University Clinical Center Kragujevac during 2021. All plans were done on the treatment planning system ECLIPSE-Version 15.6 (Varian). Treatment has been performed using the 3D-CRT technique. The results of the comparison of the calculated dose in the tumor and humerus using simulations show that the bulk dose to the humerus did not exceed the set expected maximums. However, clinicians need to be aware of the risk in order to expose the humerus as little as possible. The FOTELP-VOX code, a modification of the general-purpose FOTELP code, used in this study has proven to be a valid practical way to perform accurate calculations of three-dimensional dose distribution from the interactions of particles in a complex target.

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Data Availibility Statement

This manuscript has no associated data or the data will not be deposited. [Authors’ comment: This manuscript primarily focuses on theoretical aspects, and as such, no experimental or empirical data were collected. The research conducted for this article solely involved simulations and theoretical models.]

References

  1. https://cutt.ly/KCeMB11

  2. M. Algara, M. Arenas, D. De Las PeñasEloisa Bayo et al., Radiation techniques used in patients with breast cancer: results of a survey in Spain. Rep. Pract. Oncol. Radiother. 17, 122–128 (2012)

    Article  Google Scholar 

  3. M. Clarke, R. Collins, S. Darby et al., Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 17, 2087–106 (2005)

    Google Scholar 

  4. N. Dogan, L. Cuttino, R. Lloyd et al., Optimized dose coverage of regional lymph nodes in breast cancer: the role of intensity-modulated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 68, 1238–1250 (2007)

    Article  Google Scholar 

  5. L. Belaidi, P. Loap, Y. Kirova, Do we need to delineate the humeral head in breast cancer patients. Cancers (Basel) 14(3), 496 (2022)

    Article  Google Scholar 

  6. C.I. Dickie, A.L. Parent, A.M. Griffin et al., Bone fractures following external beamradiotherapy and limb-preservation surgery for lower extremity soft tissue sarcoma: Relationship to irradiated bone length, volume, tumor location and dose. Int. J. Radiat. Oncol. Biol. Phys. 75, 1119–1124 (2009)

    Article  Google Scholar 

  7. C.B.G. Soares, I.D. Araújo, B.J. Pádua et al., Pathological fracture after radiotherapy: systematic review of literature. Rev. Assoc. Med. Bras. 65, 902–908 (2019)

    Article  Google Scholar 

  8. W. David, O. Rogers, Fifty years of Monte Carlo simulations for medical physics. Phys. Med. Biol. 51, 13 (2006)

    Google Scholar 

  9. R.D. Ilić et al., The Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data. Phys. Med. Biol. 50, 1011 (2005)

    Article  Google Scholar 

  10. G.C. Pereira, M. Traughber, R.F. Muzic, The role of imaging in radiation therapy planning: past, present, and future. Biomed. Res. Int. 1–9 (2014)

  11. W. Schneider, T. Bortfeld, W. Schlegel, Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions. Phys. Med. Biol. 45, 459–478 (2000)

    Article  Google Scholar 

  12. H.J. Burstein, G. Curigliano, B. Thürlimann, et. al., Panelists of the St Gallen Consensus Conference. Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol. 2021 Oct. 32, 1216–1235 (2021)

  13. https://www.nccn.org/

  14. B.V. Offersen, L.J. Boersma, C. Kirkove et al., ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother. Oncol. 114, 3–10 (2015). https://doi.org/10.1016/j.radonc.2014.11.030

    Article  Google Scholar 

  15. International Commission on Radiation Units and Measurements Prescribing, recording and reporting photon beam therapy (Supplement to ICRU Report 50). ICRU Report 62. ICRU. Bethesda, USA (1999)

  16. The International Commission on Radiation Units and Measurements, Prescribing, recording, and reporting photon beam intensity modulated radiation therapy (IMRT). ICRU Report 83. J ICRU 10, 1–106 (2010)

    Article  Google Scholar 

  17. A. Özseven, E. Elif Özkan, Dosimetric evaluation of field-in-field and sliding-window IMRT in endometrium cancer patients with a new approach for the conformity index. Int. J. Radiat. Res. 18, 853–862 (2020)

    Article  Google Scholar 

  18. R.D. Ilić, Proton Therapy Monte Carlo SRNA-VOX code. Nucl. Technol. Radiat. Prot. 27, 355–367 (2012)

    Article  Google Scholar 

  19. M.P. Živković, T.B. Miladinović, A.M. Miladinović et al., Absorbed dose distribution in human eye simulated by FOTELP-VOX code and verified by volumetric modulated arc therapy treatment plan. Nucl. Technol. Radiat. Prot. 37, 78–83 (2022)

    Article  Google Scholar 

  20. B. Emami, J. Lyman, A. Brown et al., Tolerance of normal tissue to therapeutic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 21, 109–122 (1991)

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the Ministry of Education, Science and Technological Development of Serbia through the Agreements No. 451-03-47/2023-01/200122 and 451-03-47/2023-01/200378. The authors would like to thank Prof. dr Radovan D. Ilic, who introduced us to the technology of the Monte Carlo method and enabled the use of all versions of the FOTELP software package. We would also like to thank him for his unselfish professional assistance, persistence, and understanding during the paper writing.

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Authors and Affiliations

  1. Faculty of Science, University of Kragujevac, Kragujevac, Serbia

    Milena Živković & Dragana Krstić

  2. Institute for Information Technologies, University of Kragujevac, Kragujevac, Serbia

    Tatjana B. Miladinović

  3. Centre for Radiation Oncology, University Clinical Centre Kragujevac, Kragujevac, Serbia

    Neda Milosavljević & Marija Živković Radojević

  4. Department of Clinical Oncology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

    Neda Milosavljević & Marija Živković Radojević

  5. Medical Physics Department, University Clinical Center Kragujevac, Kragujevac, Serbia

    Aleksandar Miladinović

Authors
  1. Milena Živković
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  2. Tatjana B. Miladinović
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  4. Neda Milosavljević
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Correspondence to Milena Živković.

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Živković, M., Miladinović, T.B., Krstić, D. et al. Humerus absorbed dose in breast cancer postoperative radiotherapy. Simulation with FOTELP-VOX code and comparison with treatment planning system. Eur. Phys. J. Spec. Top. 232, 1549–1553 (2023). https://doi.org/10.1140/epjs/s11734-023-00893-7

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