Abstract
The presented results in this study are focused on the theoretical modeling of protein syntheses by considering the environment temperature. Considering that temperature appears in the role of chemical potential in the process of protein synthesis, we can witness a different face of the mRNA and protein degradation rate effective mode and ranges. It seems that the difference between the analytical modeling results and the experimental results is due to the lack of attention to the limiting effect of temperature in the gene expression process. The inhibitory role of the protein degradation rate in the process becomes more prominent by considering the temperature, and the influence of the mRNA degradation rate on the increase in the mRNA level decreases. In addition, the modeling shows that the time required for the gene level to reach its maximum level will be an explicit function of the environment temperature. The tendency of the gene level to reach the constant value will be with fluctuations, while the fluctuation range in mRNA level is moderated by temperature. This study has tried to verify the predictions by the experimental results. The study of fractal dimension and entropy has determined the possibility of observing the limits and rhythm of changes in the protein synthesis process.
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Nemati, F., Behnia, S. Modeling heat bath and probing environmental temperature effect in gene expression. Eur. Phys. J. Plus 138, 248 (2023). https://doi.org/10.1140/epjp/s13360-023-03869-7
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DOI: https://doi.org/10.1140/epjp/s13360-023-03869-7