Abstract
The efficient thermal damage of the malignant tissues (tumors) is the main goal in the Magnetic Hyperthermia method. The magnetic nanoparticles (MNPs) transport is strongly related to the tissue parameters as the porosity and the permeability. When an external time-dependent magnetic field is applied, the spatial and temporal distributions of MNPs have a fundamental role in the thermal damage of the malignant tissues. This paper describes the influence of the tissues’ porosity on the therapeutic temperature field which determines the thermal damage of the malignant tissues. The supplementary effects related to the spatial re-distribution of the nanoparticles as a result of thermal damage-dependent porosity were discussed for the case of the constant tissue porosity. The optimum (MNP) doses needed to obtain the therapeutic temperature range (42 ÷ 46 °C) are computed for the malignant tissues. In the numerical model, the frequency f(kHz) and amplitude of the AC magnetic field are optimized to obtain the therapeutic temperature range with the maximum thermal damage. The model contains a complex analysis regarding the injection of the ferrofluid, the spatial distribution of MNPs (after their injection) and the thermal damage of the malignant tissues.
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Astefanoaei, I., Stancu, A. Thermo-fluid porosity-related effects in the magnetic hyperthermia. Eur. Phys. J. Plus 136, 1216 (2021). https://doi.org/10.1140/epjp/s13360-021-02229-7
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DOI: https://doi.org/10.1140/epjp/s13360-021-02229-7