Abstract.
Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite® 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).
Article PDF
Similar content being viewed by others
Explore related subjects
Find the latest articles, discoveries, and news in related topics.Avoid common mistakes on your manuscript.
References
M. Parani, G. Lokhande, A. Singh, A.K. Gaharwar, ACS Appl. Mater. Interfaces 8, 10049 (2016)
G.D. Winter, Nature 193, 293 (1962)
E. Caló, V.V. Khutoryanskiy, Eur. Polym. J. 65, 252 (2015)
X. Du, J. Zhou, J. Shi, B. Xu, Chem. Rev. 115, 13165 (2015)
H. Yoo, H. Kim, J. Biomed. Mater. Res. Part B 85B, 326 (2008)
T.T. Reddy, A. Kano, A. Maruyama, M. Hadano, A. Takahara, Biomacromolecules 9, 1313 (2008)
Ch. Lin, A.T. Metters, Adv. Drug Deliv. Rev. 58, 1379 (2006)
E. Karadag, D. Saraydin, O. Guven, Turkish J. Chem. 21, 151 (1997)
M. Rogulska, A. Kultys, W. Podkościelny, Eur. Polym. J. 43, 1402 (2007)
Graham N., Mc-Neil M., Biomaterials 5, 27 (1984)
P. Petrini, S. Fare, A. Piva, M.C. Tanzi, J. Mater. Sci. 14, 683 (2003)
J.M. Harris, Poly(Ethylene Glycol) Chemistry (Springer Science+Business Media, New York, 1992)
M. Alexandre, P. Dubois, Mater. Sci. Eng. 28, 1 (2000)
Ch. Wu, A.K. Gaharwar, P.J. Schexnailder, G. Schmidt, Materials 3, 2986 (2010)
M. Sarmah, N. Banik, A. Hussain, A. Ramteke, H.K. Sharma, T.K. Maji, J. Mater. Sci. 50, 7303 (2015)
K. Yano, A. Usuki, A. Okada, J. Polym. Sci. Part A 35, 2289 (2000)
D.R. Katti, P. Ghosh, S. Schmidt, K.S. Katti, Biomacromolecules 6, 3276 (2005)
G. Mun, I. Suleimenov, K. Park, H. Omidian, Biomedical Applications of Hydrogel Handbook (Springer Science+Business Media, LLC, 2010)
J.S. Boateng, K.H. Matthews, H.N.E. Stevens, G.M. Eccleston, J. Pharm. Sci. 97, 2892 (2008)
J. Strankowska, L. Piszczyk, M. Strankowski, M. Danowska, K. Szutkowski, S. Jurga, J. Kwela, Eur. Phys. J. ST 222, 2179 (2013)
J. Strankowska, M. Strankowski, L. Piszczyk, J. Haponiuk, J. Kwela, Mater. Sci. Forum 714, 123 (2012)
G. Gorrasi, M. Tortora, V. Vittoria, J. Polym. Sci. 43, 2454 (2005)
E. Karadag, D. Saraydin, Polym. Bull. 48, 299 (2002)
Ch.S. Brazel, N.A. Peppas, Biomaterials 20, 721 (1999)
M. Miotke, M. Józefowicz, J. Mol. Liq. 230, 123 (2017)
A.R. Berens, H.B. Hopfenberg, Polymer 19, 489 (1978)
L. Masaro, X.X. Zhu, Progr. Polym. Sci. 24, 731 (1999)
R.W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, N. Peppas, Int. J. Pharm. 15, 25 (1983)
N.A. Peppas, P. Colombo, J. Control. Release 10, 245 (1989)
A.R. Khare, N.A. Peppas, Biomaterials 16, 559 (1995)
P.L. Ritger, N.A. Peppas, J. Control. Release 5, 23 (1987)
P.L. Ritger, N.A. Peppas, J. Control. Release 5, 37 (1987)
N.A. Peppas, J.J. Sahlin, Int. J. Pharm. 57, 169 (1989)
S.S. Ray, M. Okamoto, Progr. Polym. Sci. 28, 1539 (2003)
M. Brun, A. Lallemand, J.F. Quinson, Ch. Eyraud, Thermochim. Acta 21, 59 (1977)
M. Iza, S. Woerly, C. Danumah, S. Kaliaguine, M. Bousmina, Polymer 41, 5885 (2000)
N.A. Peppas, Pharm. Acta Helv. 60, 110 (1985)
J. Siepmann, F. Siepmann, Int. J. Pharm. 364, 328 (2008)
M. Grassi, G. Grassi, R. Lapasin, I. Colombo, Understanding Drug Release and Absorption Mechanisms (Taylor & Francis Group, New York, 2007)
M. Grassi, R. Lapasin, S. Pricl, I. Colombo, Chem. Eng. Commun. 155, 89 (1996)
J. Crank, The Mathematics of Diffusion (Clarendon Press, Oxford, 1975)
C. Aguzzi, P. Cerezo, C. Viseras, C. Caramella, Appl. Clay Sci. 36, 22 (2007)
S. Pacelli, P. Paolicelli, G. Morietti, S. Petralito, S. Di Giacomo, A. Vitalone, M.A. Casadei, Eur. Polym. J. 77, 114 (2016)
J. Chen, M. Liu, H. Liu, L. Ma, Mater. Sci. Eng. C 29, 2116 (2009)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Miotke, M., Strankowska, J., Kwela, J. et al. Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels. Eur. Phys. J. Plus 132, 401 (2017). https://doi.org/10.1140/epjp/i2017-11708-1
Received:
Accepted:
Published:
DOI: https://doi.org/10.1140/epjp/i2017-11708-1