Abstract
The rheological properties of bladder cancer cells of different invasivities have been investigated using a microrheological technique well adapted in the range [1-300Hz] of interest to understand local changes in the cytoskeleton microstructure, in particular actin fibres. Drugs disrupting actin and acto-myosin functions were used to study the resistance of such cancer cells. Results on a variety of cell lines were fitted with a model revealing the importance of two parameters, the elastic shear plateau modulus G 0 N as well as the glassy transition frequency f T. These parameters are good markers for invasiveness, with the notable exception of the cell periphery, which is stiffer for less invasive cells, and could be of importance in cancer metastasis.
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Contribution to the Focus Point on “The Physics of Cancer” edited by M. Ben Amar.
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Abidine, Y., Laurent, V.M., Michel, R. et al. Local mechanical properties of bladder cancer cells measured by AFM as a signature of metastatic potential. Eur. Phys. J. Plus 130, 202 (2015). https://doi.org/10.1140/epjp/i2015-15202-6
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DOI: https://doi.org/10.1140/epjp/i2015-15202-6