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Treatment planning in proton therapy

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Abstract

Radiotherapy treatment planning is a procedure that, using radiation beam and patient’s anatomy models as input data, produces as output the machine instructions to deliver the treatment and the expected dose distribution in the patient. Now that most proton therapy centers are moving from double scattered proton beams to active delivery systems such as pencil beam scanning (PBS), there is a need for treatment planning tools that could generate safe and effective dose distribution by taking full benefit of the potential of PBS degrees of freedom, and by avoiding the risks associated to this modality. The paper provides an overview of the current status of proton treatment planning techniques, from the creation of a patient model via imaging, to dose calculation, to the optimization of plans using intensity modulated proton therapy (IMPT). The issue of plan sensitivity to input data (“plan robustness”) is emphasized and current approaches to robust optimization are presented. Finally, current developments in “adaptive planning” and in the plan design for moving organs are shortly discussed.

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References

  1. Jikun Wei, George A. Sandison, Wen-Chien Hsi, Michael Ringor, Xiaoyi Lu, Phys. Med. Biol. 51, 5183 (2006).

    Article  Google Scholar 

  2. C.S. Olive, M.R. Kaus, V. Pekar, K. Eck, L. Spies, Segmentation- aided adaptive filtering for metal artifacts reduction in radio-therapeutic ct images, in Proceeding of SPIE, vol. 5370 (2004) pp. 1991--2002

  3. M. Bal, L. Spies, Med. Phys. 33, 2852 (2006).

    Article  Google Scholar 

  4. U. Schneider, E. Pedroni, A. Lomax, Phys. Med. Biol. 41, 111 (1996).

    Article  Google Scholar 

  5. H. Jiang, J. Seco, H. Paganetti, Med. Phys. 34, 1439 (2007).

    Article  Google Scholar 

  6. L. Hong, M. Goitein, M. Bucciolini, R. Comiskey, B. Gottschalk, S. Rosenthal, C. Serago, M. Urie, Phys. Med. Biol. 41, 1305 (1996).

    Article  Google Scholar 

  7. E. Pedroni, S. Scheib, T. Böhringer, A. Coray, M. Grossmann, S. Lin, A. Lomax, Phys. Med. Biol. 50, 541 (2005).

    Article  Google Scholar 

  8. M. Soukup, M. Fippel, M. Alber, Phys. Med. Biol. 50, 5089 (2005).

    Article  Google Scholar 

  9. B. Schaffner, E. Pedroni, A. Lomax, Phys. Med. Biol. 44, 27 (1999).

    Article  Google Scholar 

  10. T. Bortfeld, Med. Phys. 24, 2024 (1997).

    Article  Google Scholar 

  11. M. Fippel, M. Soukup, Med. Phys. 31, 2263 (2004).

    Article  Google Scholar 

  12. H. Paganetti, H. Jiang, S.-Y. Lee, H.M. Kooy, Med. Phys. 31, 2107 (2004).

    Article  Google Scholar 

  13. A. Tourovsky, A.J. Lomax, U. Schneider, E. Pedroni, Phys. Med. Biol. 50, 971 (2005).

    Article  Google Scholar 

  14. Xun Jia, Xuejun Gu, Josep Sempau, Dongju Choi, Amitava Majumdar, Steve B. Jiang, Phys. Med. Biol. 55, 3077 (2010).

    Article  Google Scholar 

  15. A. Badal, A. Badano, Med. Phys. 36, 4878 (2009).

    Article  Google Scholar 

  16. M. Urie, M. Goitein, M. Wagner, Phys. Med. Biol. 29, 553 (1984).

    Article  Google Scholar 

  17. M.F. Moyers, D.W. Miller, D.A. Bush, J.D. Slater, Int. J. Radiat. Oncol. Biol. Phys. 49, 1429 (2001).

    Article  Google Scholar 

  18. ICRU. Prescribing, recording and reporting photon beam therapy (ICRU report 50). ICRU report, pages 357--360, 1993

  19. M. van Herk, Semin. Radiat. Oncol. 14, 52 (2004).

    Article  Google Scholar 

  20. M.H. Phillips, E. Pedroni, H. Blattman, T. Boehringer, A. Coray, S. Scheib, Phys. Med. Biol. 37, 223 (1992).

    Article  Google Scholar 

  21. T. Bortfeld, K. Jokivarsi, M. Goitein, J. Kung, S.B. Jiang, Phys. Med. Biol. 47, 2203 (2002).

    Article  Google Scholar 

  22. A. Lomax, Phys. Med. Biol. 44, 185 (1999).

    Article  Google Scholar 

  23. M.L. Kessler, D.L. McShan, M.A. Epelman, K.A. Vineberg, A. Eisbruch, T.S. Lawrence, B.A. Fraass, Opt. Eng. 6, 421 (2005).

    Article  MathSciNet  MATH  Google Scholar 

  24. A. Niemierko, Med. Phys. 26, 1100 (1999).

    Google Scholar 

  25. F. Albertini, E.B. Hug, A.J. Lomax, Phys. Med. Biol. 55, 2863 (2010).

    Article  Google Scholar 

  26. D. Pflugfelder, J.J. Wilkens, H. Szymanowski, U. Oelfke, Med. Phys. 34, 1506 (2007).

    Article  Google Scholar 

  27. J.C. Stroom, H.C. de Boer, H. Huizenga, A.G. Visser, Int. J. Radiat. Oncol. Biol. Phys. 43, 905 (1999).

    Article  Google Scholar 

  28. C. Baum, M. Alber, M. Birkner, F. Nusslin, Radiother. Oncol. 78, 27 (2006).

    Article  Google Scholar 

  29. Marnix G. Witte, Joris van der Geer, Christoph Schneider, Joos V. Lebesque, Markus Alber, Marcel van Herk, Med. Phys. 34, 3544 (2007).

    Article  Google Scholar 

  30. Jan Unkelbach, Thomas Bortfeld, Benjamin C. Martin, Martin Soukup, Med. Phys. 36, 149 (2009).

    Article  Google Scholar 

  31. D. Pflugfelder, J.J. Wilkens, U. Oelfke, Phys. Med. Biol. 53, 1689 (2008).

    Article  Google Scholar 

  32. A. Fredriksson, A. Forsgren, B. Hårdemark, Med. Phys. 38, 1672 (2011).

    Article  Google Scholar 

  33. Antony J. Lomax, Eros Pedroni, Hanspeter Rutz, Gudrun Goitein, Z. Med. Phys. 14, 147 (2004).

    Google Scholar 

  34. A.J. Lomax, Phys. Med. Biol. 53, 1027 (2008).

    Article  Google Scholar 

  35. M. Schwarz, J. der Geer, M. Van Herk, J.V. Lebesque, B.J. Mijnheer, E.M.F. Damen, Int. J. Radiat. Oncol. Biol. Phys. 65, 1260 (2006).

    Article  Google Scholar 

  36. Ursula Nestle, Wolfgang Weber, Michael Hentschel, Anca-Ligia Grosu, Phys. Med. Biol. 54, R1 (2009) PMID: 19060363

    Article  Google Scholar 

  37. D. Létourneau, J.W. Wong, M. Oldham, M. Gulam, L. Watt, D.A. Jaffray, J.H. Siewerdsen, A.A. Martinez, Radiother. Oncol. 75, 279 (2005).

    Article  Google Scholar 

  38. D. Yan, F. Vicini, J. Wong, A. Martinez, Phys. Med. Biol. 42, 123 (1997).

    Article  Google Scholar 

  39. C. Bert, N. Saito, A. Schmidt, N. Chaudhri, D. Schardt, E. Rietzel, Med. Phys. 34, 4768 (2007).

    Article  Google Scholar 

  40. S.M. Zenklusen, E. Pedroni, D. Meer, Phys. Med. Biol. 55, 5103 (2010).

    Article  Google Scholar 

  41. M. von Siebenthal, G. Székely, U. Gamper, P. Boesiger, A. Lomax, P. Cattin, Phys. Med. Biol. 52, 1547 (2007).

    Article  Google Scholar 

  42. Jan-Jakob Sonke, Joos Lebesque, Marcel van Herk, Int. J. Radiat. Oncol. Biol. Phys. 70, 590 (2008).

    Article  Google Scholar 

  43. ICRU. Prescribing, recording, and reporting proton beam therapy (ICRU report 78).

  44. C. Grassberger, A. Trofimov, A. Lomax, H. Paganetti, Int. J. Radiat. Oncol. Biol. Phys. 80, 1559 (2011).

    Article  Google Scholar 

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Schwarz, M. Treatment planning in proton therapy. Eur. Phys. J. Plus 126, 67 (2011). https://doi.org/10.1140/epjp/i2011-11067-y

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