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Fractal aggregates induced by liposome-liposome interaction in the presence of Ca2+

The European Physical Journal E volume 24, pages 201–210 (2007)Cite this article

Abstract.

We present a study of the fractal dimension of clusters of large unilamellar vesicles (LUVs) formed by egg yolk phosphatidylcholine (EYPC), dimyristoylphosphocholine (DMPC) and dipalmitoylphosphocholine (DPPC) induced by Ca2+ . Fractal dimensions were calculated by application of two methods, measuring the angular dependency of the light scattered by the clusters and following the evolution of the cluster size. In all cases, the fractal dimensions fell in the range from 2.1 to 1.8, corresponding to two regimes: diffusion-limited cluster aggregation (DLCA) and reaction-limited cluster aggregation (RLCA). Whereas DMPC clusters showed a typical transition from the RLCA to the DLCA aggregation, EYPC exhibited an unusual behaviour, since the aggregation was limited for a higher concentration than the critical aggregation concentration. The behaviour of DPPC was intermediate, with a transition from the RLCA to the DLCA regimes with cluster sizes depending on Ca2+ concentration. Studies on the reversibility of the aggregates show that EYPC and DPPC clusters can be re-dispersed by dilution with water. DMPC does not present reversibility. Reversibility is evidence of the existence of secondary minima in the DLVO potential between two liposomes. To predict these secondary minima, a correction of the DLVO model was necessary taking into account a repulsive force of hydration.

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Affiliations

  1. Biophysics and Interfaces Group, Department of Applied Physics, Faculty of Physics, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

    J. Sabın, G. Prieto, J. M. Ruso & F. Sarmiento

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  1. J. Sabın
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  2. G. Prieto
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  3. J. M. Ruso
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  4. F. Sarmiento
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Correspondence to F. Sarmiento.

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Sabın, J., Prieto, G., Ruso, J.M. et al. Fractal aggregates induced by liposome-liposome interaction in the presence of Ca2+ . Eur. Phys. J. E 24, 201–210 (2007). https://doi.org/10.1140/epje/i2007-10231-3

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PACS.

  • 87.16.Dg Membranes, bilayers, and vesicles
  • 05.45.Df Fractals
  • 89.75.-k Complex systems