This EPJD special issue dedicated to the field of precision physics of simple atomic systems includes several important peer-reviewed contributions, presented on the 11th edition of the PSAS conference—initially planned to take place in May 2020 in Wuhan, China (only to be rescheduled 2 years later, in May 2022, due to the COVID-19 pandemic, in Warsaw, Poland).

The aim of the PSAS conference is to gather scientists from all over the world working on precise calculations and measurements, with the goal to test fundamental physics, to verify laws of physics, and to determine fundamental constants. Correspondingly, a mix of theoretical, numerical and experimental works spanning the fields of spectroscopy of atomic and molecular hydrogen, QED of few-electron bound systems, exotic atoms and ions, searches for BSM physics with atoms and antimatter, clocks, measurements of g-2 and alpha, originating from several of the major groups in this field, are reported here, making the current collection of interest for both the younger generation entering this research field and experts for efficient access on recent developments.