Abstract
X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results were examined against a common cancer chemotherapy drug cis-diamminedichloroplatinum (II). It was found that platinum (II) bromide can greatly increase the levels of single- and double-strand break formation observed in the irradiated samples with respect to the samples containing platinum as a radiosensitizer only, possessing very little chemotherapeutic activity. The suggested drugs exhibit much higher level of radiosensitivity than widely used cisplatin and thus may be good candidates for cancer treatment.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
T.S. Lawrence, A.W. Blackstock, C. McGinn, Semin. Radiat. Oncol. 13, 13 (2003)
Y.P. Ho, S.C.F. Au-Yeung, K.K.W. To, Med. Res. Rev. 23, 633 (2003)
J. Reedijk, Eur. J. Inorg. Chem. 2009, 1303 (2009)
B. Boudaïffa, P. Cloutier, D. Hunting, M.A. Huels, L. Sanche, Science 287, 1658 (2000)
I. Baccarelli, I. Bald, F.A. Gianturco, E. Illenberger, J. Kopyra, Phys. Rep. 508, 1 (2011)
L. Sanche, in Radiation Damage in Biomolecular Systems, edited by G. García Gómez-Tejedor (Springer, 2012)
M. Rezaee, J.D. Hunting, L. Sanche, Int. J. Radiat. Biol. 80, 841 (2004)
G. Chu, J. Biol. Chem. 269, 787 (1994)
M. Rezaee, D.J. Hunting, L. Sanche, Int. J. Radiat. Oncol. Biol. Phys. 87, 847 (2013)
M. Maeda, K. Kobayashi, K. Hieda, Int. J. Radiat. Biol. 80, 841 (2004)
C. Le Sech, K. Takakura, C. Saint-Marc, H. Frohlich, M. Charlier, N. Usami, K. Kobayashi, Radiat. Res. 153, 454 (2000)
A.T.C. Chan, S.F. Leung, R.K.C. Ngan, P.M.L. Teo, W.H. Lau, W.H. Kwan, E.P. Hui, H.Y. Yiu, W. Yeo, F.Y. Cheung, K.H. Yu, K.W. Chiu, D.T. Chan, T.S.K. Mok, S. Yau, K.T. Yuen, F.K.F. Mo, M.M.P. Lai, B.B.Y. Ma, M.K.M. Kam, T.W.T. Leung, P.J. Johnson, P.H. Choi, B.C. Zee, J. Natl. Cancer Instit. 97, 536 (2005)
M.R. Detty, S.L. Gibson, S.J. Wagner, J. Med. Chem. 47, 3897 (2004)
M.A. Bagshaw, R.L. Doggett, K.C. Smith, H.S. Kaplan, T.S. Nelsen, Am. J. Roentgenol. Radium Therapy Nucl. Med. 99, 886 (1967)
M.A. Śmiałek, S.V. Hoffmann, M. Folkard, K.M. Prise, D.E.G. Shuker, N.S. Braithwaite, N.J. Mason, Radiat. Damage Biomol. Syst. 101, 12020 (2008)
M.A. Śmiałek, S.A. Moore, N.J. Mason, D.E.G. Shuker, Radiat. Res. 172, 529 (2009)
K. Kobayashi, N. Usami, I. Sasaki, H. Frohlich, C. Le Sech, Nucl. Instrum. Methods Phys. Res. B 199, 348 (2003)
M.A. Śmiałek, R. Balog, N.C. Jones, D. Field, N.J. Mason, Eur. Phys. J. D 60, 31 (2010)
K. Nakamoto, P.J. McCarthy, J. Fujita, R.A. Condrate, G.T. Behnke, Inorg. Chem. 4, 36 (1965)
M.A. Śmiałek, N.C. Jones, R. Balog, N.J. Mason, D. Field, Eur. Phys. J. D 62, 197 (2011)
NIST Chemistry WebBook, http://webbook.nist.gov/chemistry
S.J. Lippard, Pure Appl. Chem. 59, 731742 (1987)
K. Tanzer, A. Pelc, S. Huber, M.A. Śmiałek, P. Scheier, M. Probst, S. Denifl, Int. J. Mass Spectrom. (2013), in press, http://dx.doi.org/10.1016/j.ijms.2013.11.016
L. Nahon, P. Morin, F. Combetfarnoux, Phys. Scr. 41, 104 (1992)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
About this article
Cite this article
Śmiałek, M., Ptasińska, S., Gow, J. et al. Radiosensitization of DNA in presence of Pt(II)-based compounds. Eur. Phys. J. D 68, 85 (2014). https://doi.org/10.1140/epjd/e2014-40846-7
Received:
Revised:
Published:
DOI: https://doi.org/10.1140/epjd/e2014-40846-7