Modelling low energy electron and positron tracks in biologically relevant media

  • Francisco Blanco
  • Antonio Muñoz
  • Diogo Almeida
  • Filipe Ferreira da Silva
  • Paulo Limão-Vieira
  • Martina C. Fuss
  • Ana G. Sanz
  • Gustavo García
Colloquium

Abstract

This colloquium describes an approach to incorporate into radiation damage models the effect of low and intermediate energy (0–100 eV) electrons and positrons, slowing down in biologically relevant materials (water and representative biomolecules). The core of the modelling procedure is a C++ computing programme named “Low Energy Particle Track Simulation (LEPTS)”, which is compatible with available general purpose Monte Carlo packages. Input parameters are carefully selected from theoretical and experimental cross section data and energy loss distribution functions. Data sources used for this purpose are reviewed showing examples of electron and positron cross section and energy loss data for interactions with different media of increasing complexity: atoms, molecules, clusters and condense matter. Finally, we show how such a model can be used to develop an effective dosimetric tool at the molecular level (i.e. nanodosimetry). Recent experimental developments to study the fragmentation induced in biologically material by charge transfer from neutrals and negative ions are also included.

Keywords

Colloquium 

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Copyright information

© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Francisco Blanco
    • 1
  • Antonio Muñoz
    • 2
  • Diogo Almeida
    • 3
  • Filipe Ferreira da Silva
    • 3
  • Paulo Limão-Vieira
    • 3
  • Martina C. Fuss
    • 4
  • Ana G. Sanz
    • 4
  • Gustavo García
    • 4
    • 5
  1. 1.Departamento de Física Atómica, Molecular y NuclearUniversidad Complutense de MadridMadridSpain
  2. 2.Centro de Investigaciones Energéticas Medioambientales y TecnológicasMadridSpain
  3. 3.Laboratório de Colisões Atómicas e Moleculares, CEFITEC, Departamento de Física, Faculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparicaPortugal
  4. 4.Instituto de Física FundamentalConsejo Superior de Investigaciones CientíficasMadridSpain
  5. 5.Centre for Medical Radiation PhysicsUniversity of WollongongWollongongAustralia

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