Electrosprayed droplet impact/secondary ion mass spectrometry

  • K. HiraokaEmail author
  • D. Asakawa
  • S. Fujimaki
  • A. Takamizawa
  • K. Mori
New Experimental Developments


A new ionization method, electrosprayed droplet impact ionization (EDI), has been developed for mass spectrometry. The charged droplets formed by electrospraying 1 M acetic acid aqueous solution are sampled through an orifice with a diameter of 400 μm into the first vacuum chamber, transported into a quadrupole ion guide and accelerated by 10 kV after exiting the ion guide. The m/z of the primary droplet projectiles range from 10 000 to 50 000. The droplets impact on a dry solid sample deposited on a stainless steel substrate. No matrix was used for the sample preparation. The secondary ions formed by the impact are transported to a second quadrupole ion guide and mass-analyzed by an orthogonal TOF-MS. Intense molecular-related ions are detected for drugs, amino acids, peptides and proteins. EDI is found to be very sensitive to molecules present near the surface of the sample.


34.50.Dy Interactions of atoms and molecules with surfaces; photon and electron emission; neutralization of ions 36.40.Gk Plasma and collective effects in clusters 39.10.+j Atomic and molecular beam sources and techniques 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. A. Takamizawa, S. Fujimaki, J. Sunner, K. Hiraoka, J. Am. Soc. Mass Spectrom. 16, 860 (2005) CrossRefGoogle Scholar
  2. B. Sundqvist, R.D. Macfarlane, Mass Spectrom. Rev. 4, 421 (1985) CrossRefGoogle Scholar
  3. M. Barber, R.S. Bordoli, R.D. Sedwick, A.N. Tyler, J. Chem. Soc. Chem. Commun. 325 (1981) Google Scholar
  4. W. Aberth, K.M. Straub, A.L. Burlingame, Anal. Chem. 54, 2029 (1982) CrossRefGoogle Scholar
  5. R.J. Beuhler, L. Friedman, Int. J. Mass Spectrom. Ion Process. 94, 25 (1989) CrossRefGoogle Scholar
  6. A. Brundle, P. Chaurand, S. Delola-Negra, G.B. Baptista, Int. J. Mass Spectrom. Ion Process. 126, 65 (1993) CrossRefGoogle Scholar
  7. Z. Postawa, J. Phys. Chem. B 108, 7831 (2004) CrossRefGoogle Scholar
  8. M.G. Blain, Phys. Rev. Lett. 63, 1625 (1989) CrossRefADSGoogle Scholar
  9. A. Novikov, M. Caroff, S. Della-Negra, J. Depauw, M. Fallavier, Y.L. Beyec, M. Pautrat, J.A. Schultz, A. Tempez, A.S. Woods, (Rapid Commun.) Mass spectrom. 19, 1851 (2005) CrossRefGoogle Scholar
  10. N. Winograd, Anal. Chem. April 1, 143A (2005) Google Scholar
  11. F. Eusepi, A. Tomsic, C.R. Gebhardt, Anal. Chem. 75, 5124 (2003) CrossRefGoogle Scholar
  12. J.F. Mahoney, J. Perel, S.A. Ruatta, P.A. Martino, S. Husain, T.D. Lee, (Rapid Commun.) Mass Spectrom. 5, 441 (1991) CrossRefGoogle Scholar
  13. J.F. Mahoney, J. Perel, T.D. Lee, P.A. Martino, P. Williams, J. Am. Soc. Mass Spectrom. 3, 311 (1992) CrossRefGoogle Scholar
  14. J.F. Mahoney, D.S. Cornett, T.D. Lee, (Rapid Commun.) Mass Spectrom. 8, 403 (1994) CrossRefGoogle Scholar
  15. D.S. Cornett, T.D. Lee, J.F. Mahoney, (Rapid Commun.) Mass Spectrom. 8, 996 (1994) CrossRefGoogle Scholar
  16. 53rd ASMS confererence, ThP 229, San Antonio, Texas, 2005 Google Scholar
  17. J.M. McMahon, N.N. Dookeran, P.J. Todd, J. Am. Soc. Mass Spectrom. 6, 1047 (1995) CrossRefGoogle Scholar
  18. S.A. Aksyonov, P. Williams, (Rapid Commun.) Mass Spectrom. 15, 2001 (2001) CrossRefGoogle Scholar

Copyright information

© EDP Sciences/Società Italiana di Fisica/Springer-Verlag 2005

Authors and Affiliations

  • K. Hiraoka
    • 1
    Email author
  • D. Asakawa
    • 1
  • S. Fujimaki
    • 1
  • A. Takamizawa
    • 1
  • K. Mori
    • 1
  1. 1.Clean Energy Research Center, University of YamanashiKofuJapan

Personalised recommendations