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Hybrid Bio-Mag-MEMS combining magnetophoresis and dielectrophoresis

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Abstract

The design of a new hybrid magnetic MEMS for biology (Bio-Mag-MEMS) is presented. It combines magnetophoresis, dielectrophoresis and microfluidics. These phenomena are used to sort magnetically tagged and non-tagged objects. Magnetic objects are trapped by the use of high gradient magnetophoresis. Thanks to dielectrophoresis these objects, once trapped, can be successfully released in a buffer. Efficient sorting is performed in this hybrid Bio-Mag-MEMS by using magnetic beads. A high sorting efficiency is demonstrated. Magnetic, Stokes and dielectrophoretic forces in the microfluidic channel are simulated with both analytical tools and the finite element method (FEM). The trajectories of magnetically tagged objects are simulated. Finally the fabrication and optimization of this device are detailed.

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Authors and Affiliations

  1. G2Elab, CNRS UMR 5269 and Grenoble University, BP 46, 38402, St. Martin d’Hères, France

    Guillaume Blaire, Alain Masse, Luiz Fernando Zanini, Victor Gaude, Sarah Delshadi, Orphée Cugat & Gilbert Reyne

  2. LMGP, CNRS UMR 5628 and Grenoble-INP, BP 257, Grenoble, France

    Guillaume Blaire, Marianne Weidenhaupt & Franz Bruckert

  3. Néel Institute, CNRS UPR 2940 and Joseph Fourier University, BP 166, 38042, Grenoble Cedex 9, France

    Luiz Fernando Zanini & Frédéric Dumas-Bouchiat

  4. LTM, CNRS UMR 5129 and CEA Grenoble, 38054, Grenoble, France

    Thibault Honegger & David Peyrade

Authors
  1. Guillaume Blaire
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  2. Alain Masse
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  3. Luiz Fernando Zanini
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  4. Victor Gaude
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  5. Sarah Delshadi
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  6. Thibault Honegger
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  7. David Peyrade
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  8. Marianne Weidenhaupt
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  9. Frédéric Dumas-Bouchiat
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  10. Franz Bruckert
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  11. Orphée Cugat
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  12. Gilbert Reyne
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Corresponding author

Correspondence to Guillaume Blaire.

Additional information

Contribution to the Topical Issue “New Trends in Magnetism and Magnetic Materials”, edited by Francesca Casoli, Massimo Solzi and Paola Tiberto.

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Blaire, G., Masse, A., Zanini, L.F. et al. Hybrid Bio-Mag-MEMS combining magnetophoresis and dielectrophoresis. Eur. Phys. J. B 86, 165 (2013). https://doi.org/10.1140/epjb/e2013-30679-1

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  • DOI: https://doi.org/10.1140/epjb/e2013-30679-1

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