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Optimization of the bio-functionalized area of magnetic biosensors

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Abstract

In this work, calculations and preliminary experimental data for determining the optimal condition for the selective bio-functionalization of magnetic tunneling junction (MTJ)-based biosensors are presented. Results on the detection of biomolecular recognition events employing MTJ-based sensor and magnetic beads are presented and interpreted through calculations, taking into account the dependence of the signal on the distribution of the beads with respect to the sensor. Furthermore, it is demonstrated by calculations that a significant increase in the sensor sensitivity and quantification capability can be achieved by selectively bio-functionalizing an area which corresponds to the sensor active area.

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Authors and Affiliations

  1. L-NESS and CNISM, Dipartimento di Fisica, Politecnico di Milano, Via Anzani 42, 22100, Como, Italy

    Edoardo Albisetti, Daniela Petti & Riccardo Bertacco

  2. Istituto di Chimica del Riconoscimento Molecolare, CNR, Via Mario Bianco 9, 20131, Milan, Italy

    Edoardo Albisetti, Francesco Damin, Marina Cretich, Marta Bagnati, Laura Sola & Marcella Chiari

Authors
  1. Edoardo Albisetti
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  2. Daniela Petti
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  3. Francesco Damin
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  4. Marina Cretich
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  5. Marta Bagnati
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  6. Laura Sola
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  7. Marcella Chiari
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  8. Riccardo Bertacco
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Correspondence to Edoardo Albisetti.

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Albisetti, E., Petti, D., Damin, F. et al. Optimization of the bio-functionalized area of magnetic biosensors. Eur. Phys. J. B 86, 261 (2013). https://doi.org/10.1140/epjb/e2013-30676-4

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  • DOI: https://doi.org/10.1140/epjb/e2013-30676-4

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