Abstract
In many cell types, intracellular calcium is released from internal stores through calcium release channels. Because these channels are distributed in clusters with a few tens of channels, the clusters show a strongly stochastic open and close dynamics, resulting in noisy localized Ca2+ signals called puffs. Using the Li-Rinzel model we compare the stochastic channel simulations for the Markov method and three different Langevin approaches. We suggest that a modified Langevin approach should be considered in order to more accurately simulate Markov channel noise for puff dynamics.
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Huang, Y.D., Rüdiger, S. & Shuai, J.W. Modified Langevin approach for a stochastic calcium puff model. Eur. Phys. J. B 83, 401 (2011). https://doi.org/10.1140/epjb/e2011-20517-y
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DOI: https://doi.org/10.1140/epjb/e2011-20517-y