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The European Physical Journal B

, Volume 65, Issue 3, pp 435–442 | Cite as

Monitoring noise-resonant effects in cancer growth influenced by external fluctuations and periodic treatment

  • A. FiasconaroEmail author
  • A. Ochab-Marcinek
  • B. Spagnolo
  • E. Gudowska-Nowak
Article

Abstract

We investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumor and immune cells populations is based on the generic Michaelis-Menten kinetics depicting interaction and competition between the tumor and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and exhibits bistability within a given choice of the immune response-related parameters. Under the influence of weak external fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation, modeling a periodic treatment, is insufficient to overcome the barrier height and to cause cancer extinction. In this case the presence of a small amount of noise can positively enhance the treatment, driving the system to a state of tumor extinction. On the other hand, however, the same noise can give rise to return effects up to a stochastic resonance behavior. This observation provides a quantitative analysis of mechanisms responsible for optimization of periodic tumor therapy in the presence of spontaneous external noise. Studying the behavior of the extinction time as a function of the treatment frequency, we have also found the typical resonant activation effect: For a certain frequency of the treatment, there exists a minimum extinction time.

PACS

05.40.-a Fluctuation phenomena, random processes, noise, and Brownian motion 87.17.Aa Modeling, computer simulation of cell processes 87.15.A-Theory, modeling, and computer simulation 

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Copyright information

© Springer 2008

Authors and Affiliations

  • A. Fiasconaro
    • 1
    • 2
    • 3
    Email author
  • A. Ochab-Marcinek
    • 2
    • 4
  • B. Spagnolo
    • 3
  • E. Gudowska-Nowak
    • 1
    • 2
  1. 1.Mark Kac Complex Systems Research CenterJagellonian UniversityKrak’owPoland
  2. 2.Marian Smoluchowski Institute of PhysicsJagellonian UniversityKrak’owPoland
  3. 3.Dipartimento di Fisica e Tecnologie Relative and CNISM, Group of Interdisciplinary PhysicsUniversità di PalermoPalermoItaly
  4. 4.Institut für PhysikUniversität Augsburg, Universitätsstraβe 1AugsburgGermany

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