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The European Physical Journal Special Topics

, Volume 227, Issue 7–9, pp 883–893 | Cite as

Synchronization structure of evolving epileptic networks using cross-entropy

  • Abner Cardoso Rodrigues
  • Luis Otavio Sales Ferreira Caboclo
  • Hilda Alicia Cerdeira
  • Edson AmaroJr.
  • Birajara Soares Machado
Regular Article
  • 21 Downloads
Part of the following topical collections:
  1. Nonlinear Effects in Life Sciences

Abstract

In this paper we present connectivity patterns of evolving large scale epileptic networks. We employed a cross-entropy measure in the frequency domain on EEG signals to infer the networks, before and during episodes of epileptic seizures. This measure allowed us to make a richer portrait about the node interactions on the graph and to identify emergent structures associated with the synchronization of brain activity. Our results points to a more complex scenario of network organization than the synchronized/unsynchronized dichotomy, with two main results: first, showing regions with unsynchronized (or independent) behavior, even during absence seizures, contradicting the concept of hypersynchrony. Furthermore, we explore the cross-entropy fluctuations along the seizure: a group of nodes became more similar over time while another group became more different, showing a complementary behaviour and different local brain activities. These results bring new questions about the spreading and the sustenance of the epileptic seizures and others synchronization phenomena in living systems.

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Copyright information

© EDP Sciences and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Abner Cardoso Rodrigues
    • 1
  • Luis Otavio Sales Ferreira Caboclo
    • 2
  • Hilda Alicia Cerdeira
    • 3
    • 4
  • Edson AmaroJr.
    • 2
  • Birajara Soares Machado
    • 2
  1. 1.Instituto de Matemática e Estatística, Universidade de São PauloSão PauloBrazil
  2. 2.Hospital Israelita Albert EinsteinSão PauloBrazil
  3. 3.São Paulo State University (UNESP), Instituto de Física TeóricaSão PauloBrazil
  4. 4.Epistemic, Department of ResearchSão PauloBrazil

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