The European Physical Journal Special Topics

, Volume 226, Issue 5, pp 881–888 | Cite as

The topological pressure-temperature phase diagram of fluoxetine nitrate: monotropy unexpectedly turning into enantiotropy

  • René CéolinEmail author
  • Ivo B. Rietveld
Regular Article
Part of the following topical collections:
  1. Phase Equilibria and Their Applications


The phase behavior of pharmaceuticals is important for regulatory requirements and dosage form development. Racemic fluoxetine nitrate possesses two crystalline forms for which initial measurements indicated that they have a monotropic relationship with form I the only stable form. By constructing the topological pressure-temperature phase diagram, it has been shown that unexpectedly form II has a stable domain in the phase diagram and can be easily obtained by heating and grinding. The pressure necessary to obtain form II is only 11 MPa, which is much lower than most pressure used for tableting in the pharmaceutical industry.


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Copyright information

© EDP Sciences and Springer 2017

Authors and Affiliations

  1. 1.LETIAM, EA7357, IUT Orsay, Université Paris Sud, rue NoetzlinOrsay CedexFrance
  2. 2.Caractérisation des Matériaux Moléculaires à Activité Thérapeutique (CAMMAT), Faculté de Pharmacie, Université Paris DescartesParisFrance

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