The European Physical Journal Special Topics

, Volume 226, Issue 3, pp 353–363 | Cite as

Modelling the dynamics of stem cells in colonic crypts

  • Orozco-Fuentes Sirio
  • Rafael A. BarrioEmail author
Regular Article
Part of the following topical collections:
  1. Nonlinearity, Nonequilibrium and Complexity: Questions and Perspectives in Statistical Physics


We present a theoretical and computational framework to model the colonic crypt organisation in the human intestine. We construct a theoretical and computational framework to model the colonic crypt behaviour, using a Voronoi tessellation to represent each cell and elastic forces between them we addressed how their dynamical disfunction can lead to tumour masses and cancer. Our results indicate that for certain parameters the crypt is in a homeostatic state, but slight changes on their values can disrupt this behaviour.


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© EDP Sciences and Springer 2017

Authors and Affiliations

  1. 1.Instituto de Física, Universidad Nacional Autónoma de MéxicoMéxico D.F.Mexico

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