The European Physical Journal Special Topics

, Volume 226, Issue 3, pp 353–363

Modelling the dynamics of stem cells in colonic crypts

Regular Article

DOI: 10.1140/epjst/e2016-60177-8

Cite this article as:
Sirio, OF. & Barrio, R.A. Eur. Phys. J. Spec. Top. (2017) 226: 353. doi:10.1140/epjst/e2016-60177-8
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Part of the following topical collections:
  1. Nonlinearity, Nonequilibrium and Complexity: Questions and Perspectives in Statistical Physics

Abstract

We present a theoretical and computational framework to model the colonic crypt organisation in the human intestine. We construct a theoretical and computational framework to model the colonic crypt behaviour, using a Voronoi tessellation to represent each cell and elastic forces between them we addressed how their dynamical disfunction can lead to tumour masses and cancer. Our results indicate that for certain parameters the crypt is in a homeostatic state, but slight changes on their values can disrupt this behaviour.

Copyright information

© EDP Sciences and Springer 2017

Authors and Affiliations

  1. 1.Instituto de Física, Universidad Nacional Autónoma de MéxicoMéxico D.F.Mexico

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