The European Physical Journal Special Topics

, Volume 225, Issue 4, pp 767–771 | Cite as

Incorporation of tramadol drug into Li-fluorohectorite clay: A preliminary study of a medical nanofluid

  • L. Valdés
  • D. Hernández
  • L. Ch. de Ménorval
  • I. Pérez
  • E. Altshuler
  • J.O. FossumEmail author
  • A. RiveraEmail author
Regular Article
Part of the following topical collections:
  1. Cooperative Particles: Patchy Colloids, Active Matter and Nanofluids


During the last years, clays have been increasingly explored as hosts for drugs. In the present paper, we have been able to host the non-steroidal anti-inflammatory drug, Tramadol, into the clay Li-fluorohectorite (Li-Fh). We preliminary evaluate its incorporation by means of UV spectroscopy and X ray diffraction. Our results indicate that the clay hosts the drug molecule in its interlayer space. We suggest a set of parameters to guarantee an efficient incorporation process. Future studies will concentrate on the release of the drug from the clay nanofluid.


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Copyright information

© EDP Sciences and Springer 2016

Authors and Affiliations

  • L. Valdés
    • 1
  • D. Hernández
    • 2
  • L. Ch. de Ménorval
    • 3
  • I. Pérez
    • 1
  • E. Altshuler
    • 4
  • J.O. Fossum
    • 5
    Email author
  • A. Rivera
    • 2
    Email author
  1. 1.Institute of Pharmacy and Food (IFAL), University of HavanaHabanaCuba
  2. 2.Institute of Materials Science and Technology (IMRE), University of HavanaHabanaCuba
  3. 3.Equipe Agrégats, Interface, et Materiaux pour l’Energie, Université MontpellierMontpellierFrance
  4. 4.Group of Complex Systems and Statistical Physics, Physics Faculty, University of HavanaHabanaCuba
  5. 5.Norwegian University of Science and Technology (NTNU)TrondheimNorway

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