The European Physical Journal Special Topics

, Volume 223, Issue 9, pp 1831–1847 | Cite as

Looking at hydrogen motions in confinement

The uniqueness of Quasi-Elastic Neutron Scattering
  • J. Fischer
  • N. Tsapatsaris
  • E. de Paula
  • H. N. Bordallo
Part of the following topical collections:
  1. Soft Matter in Confinement: Systems from Biology to Physics


Why in a barren and hot desert, clays can contain a significant fraction of water? Why does concrete crack? How can we demonstrate that complexation of a drug does not alter its conformation in a way that affects its functionality? In this paper we present results on various studies using Quasi-Elastic Neutron Scattering aimed at clarifying these questions. To allow for a better understanding of neutron scattering, a brief introduction to the basics of its theory is presented. Following the theoretical part, experimental results dealing with the effects of confinement on the water dynamics caused by the interfaces in clays and the nano- and micro-pores of concrete are reviewed in detail. At the end, recent Quasi-Elastic Neutron Scattering investigations on the complexation of the local anesthetics Bupivacaine (BVC.HCl, C18H28N20.HCl.H2O) and Ropivacaine (RVC.HCl, C17H26N20.HCl.H2O) into the cyclic β-cyclodextrin oligosaccharide are presented. To conclude, the perspectives that the European Spallation Source brings to this subject are discussed.


European Physical Journal Special Topic Ropivacaine Cement Paste Interlayer Water Tricalcium Silicate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    G.E. Bacon, Neutron Scattering in Chemistry (Butterworths, London, 1977)Google Scholar
  2. 2.
    V.F. Sears, Neutron News 3, 26 (1992)CrossRefGoogle Scholar
  3. 3.
    S.W. Lovesey, Theory of Neutron Scattering from Condensed Matter (Claredon Press, Oxford, 1984)Google Scholar
  4. 4.
    P. Schuster, G. Zundel, C. Sandorfy, The Hydrogen Bond, Vol. III (North-Holland Publishing Company, Amsterdam, 1976)Google Scholar
  5. 5.
    M. Bee, Physica B 182, S323 (1992)CrossRefADSGoogle Scholar
  6. 6.
    R.E. Lechner, R. Melzer, J. Fitter, Physica B 226, S86 (1996)CrossRefADSGoogle Scholar
  7. 7.
    S. Rols, J. Herve, H. Schober, C. R. Phys. 8, S777 (2007)CrossRefADSGoogle Scholar
  8. 8.
    J.-B. Brubach, A. Mermet, A. Filabozzi, A. Gerschel, D. Lairez, M.P. Krafft, P. Roy, J. Phys. Chem. 105, 430 (2001)CrossRefGoogle Scholar
  9. 9.
    H. Kyakuno, K. Matsuda, H. Yahiro, Y. Inami, T. Fukuoka, Y. Miyata, K. Yanagi, Y. Maniwa, H. Kataura, T. Saito, M. Yumura, S. Iijima, J. Chem. Phys. 134, 244501 (2011)CrossRefADSGoogle Scholar
  10. 10.
    J. Jacobsen, M.S. Rodrigues, M.T.F. Telling, A.L. Beraldo, S.F. Santos, L.P. Aldridge, H.N. Bordallo, Sci. Rep. 3, 2667 (2013)CrossRefADSGoogle Scholar
  11. 11.
    K.S. Singwi, A. Sjolander, Phys. Rev. 119, 863 (1960)CrossRefADSGoogle Scholar
  12. 12.
    J. Teixeira, M.-C. Bellissent-Funel, S.H. Chen, A.J. Dianoux, Phys. Rev. A 31, 1913 (1985)CrossRefADSGoogle Scholar
  13. 13.
    H.N. Bordallo, L.P. Aldridge, P. Fouquet, L.C. Pardo, T. Unruh, J. Wuttke, F. Yokaichiya, ACS Appl. Mater. Interf. 1, 2154 (2009)CrossRefGoogle Scholar
  14. 14.
    V.F. Sears, Can. J. Phys. 44, 1299 (1966)CrossRefADSGoogle Scholar
  15. 15.
    M.-C. Bellissent-Funel, S. Chen, J.-M. Zanotti, Phys. Rev. E 51, 4558 (1995)CrossRefADSGoogle Scholar
  16. 16.
    T. Chudley, R.J. Elliot, Proc. Phys. Soc. London 77, 353 (1966)CrossRefADSGoogle Scholar
  17. 17.
    S.-H. Chen, P. Gallo, F. Sciortino, P. Tartaglia, Phys. Rev. E 56, 4231 (1997)CrossRefADSGoogle Scholar
  18. 18.
    B. Frick, H. Buttner, R. Zorn (eds.), Proceedings of the International Workshop on Dynamics in Confinement, J. Phys. IV 10 (PR7) (2000)Google Scholar
  19. 19.
    B. Frick, M. Koza, R. Zorn (eds.), Proceedings of the second International Workshop on Dynamics in Confinement, Eur. Phys. J. E 12(1) (2003)Google Scholar
  20. 20.
    M. Koza, B. Frick, R. Zorn (eds.), Proceedings of the 3rd International Workshop on Dynamics in Confinement, Eur. Phys. J. Special Topics 141(4) (2007)Google Scholar
  21. 21.
    T. Blochowicz, E. Gouirand, A. Fricke, T. Spehr, B. Stuhn, B. Frick, Chem. Phys. Lett. 475, 171 (2009)CrossRefADSGoogle Scholar
  22. 22.
    The cement sustainability initiative: Progress report, World Business Council for Sustainable Development, 2002. [Online]. Available:
  23. 23.
    P.K. Mehta, D. Manmohan, ACI Concr. Int. 28, 37 (2006)Google Scholar
  24. 24.
    C. Powers, T.L. Brownyard, Studies of the physical properties of hardened Portland cement paste (Portland Cement Association, Chicago, 1948)Google Scholar
  25. 25.
    A.M. Neville, Properties of Concrete Fourth and Final Edition (John Wiley & Sons, New York, 1996)Google Scholar
  26. 26.
    H.N. Bordallo, L.P. Aldridge, A. Desmedt, J. Phys. Chem. B 110, 17966 (2006)CrossRefGoogle Scholar
  27. 27.
    H.N. Bordallo, K.W. Herwig, B.M. Luther, N.E. Levinger, J. Chem. Phys. 121, 12457 (2004)CrossRefADSGoogle Scholar
  28. 28.
    S. Brunauer, I. Odler, M. Yudenfreund, Highway Res. Rec. 89, 328 (1970)Google Scholar
  29. 29.
    E. Fratini, A. Faraone, F. Ridi, S.-H. Chen, P. Baglioni, J. Phys. Chem. C 117, 7358 (2013)CrossRefGoogle Scholar
  30. 30.
    H.V. Damme, A. Gmira, Cement Hydrates, in Handbook of Clay Science., edited by B.K. Theng, F. Bergaya, G. Lagaly (Elsevier, Amsterdam, 2006)Google Scholar
  31. 31.
    J. Swenson, R. Bergman, W.S. Howells, J. Chem. Phys. 113, 2873 (2000)CrossRefADSGoogle Scholar
  32. 32.
    F.K. North, Petroleum Geology (Unwin-Hyman, Boston, 1990)Google Scholar
  33. 33.
    L.B. Williams, B. Canfield, K.M. Voglesonger, R. John, Geology 33, 913 (2005)CrossRefADSGoogle Scholar
  34. 34.
    P.F. Low, Physical chemistry of clay-water interaction, in Advances in Agronomy, No. 13, edited by A.G. Norman (Academic Press, New York, 1961)Google Scholar
  35. 35.
    H.N. Bordallo, L.P. Aldridge, G. Jock Churchman, W.P. Gates, M.T.F. Telling, K. Kiefer, P. Fouquet, T. Seydel, S.A.J. Kimber, J. Phys. Chem. C 112, 19982 (2008)CrossRefGoogle Scholar
  36. 36.
    N. Malikova, E. Dubois, P. Turq, J. Phys. Chem. B 110, 3206 (2006)CrossRefGoogle Scholar
  37. 37.
    I.C. Bourg, G. Sposito, G.A.C.M. Bourg, Clays and Clay Miner. 54, 363 (2006)CrossRefADSGoogle Scholar
  38. 38.
    W.P. Gates, H.N. Bordallo, L.P. Aldridge, T. Seydell, H. Jacobsen, V. Marry, G. Jock Churchman, J. Phys. Chem. C 116, 5558 (2012)CrossRefGoogle Scholar
  39. 39.
    J. Bujdak, H. Slosiarikova, J. Thermal Anal. Calorim. 41, 825 (1994)CrossRefGoogle Scholar
  40. 40.
    M. Snoeck, Local, Reg. Anesthesia 5, 23 (2012)CrossRefGoogle Scholar
  41. 41.
    E. de Paula, C.M.S. Cereda, L.F. Fraceto, D.R. de Araujo, M. Franz-Montan, G.R. Tofoli, J. Ranali, M.C. Volpato, F.C. Groppo, Expert Opin. Drug Deliv. 9, 1505 (2012)CrossRefGoogle Scholar
  42. 42.
    T. Loftsson, D. Duchen, Int. J. Pharm. 329, 1 (2007)CrossRefGoogle Scholar
  43. 43.
    R.A. Katageri, M.A. Sheikh, Int. Res. J. Pharm. 3, 52 (2012)Google Scholar
  44. 44.
    C.M. Moraes, P. Abrami, E. de Paula, A.F.A. Braga, L.F. Fraceto, Int. J. Pharm. 331, 99 (2007)CrossRefGoogle Scholar
  45. 45.
    R. Partanen, M. Ahro, M.H.H. Kallio, P. Forssell, Eur. Food Res. Technol. 214, 242 (2002)CrossRefGoogle Scholar
  46. 46.
    L.M.A. Pinto, L.F. Fraceto, M.H.A. Santana, T.A. Pertinhez, S. Oyama Junior, E. de Paula, J. Pharm. Biomed. Anal. 39, 956 (2005)CrossRefGoogle Scholar
  47. 47.
    R.A.F. de Lima, M.B. de Jesus, C.M.S. Cereda, G.R. Tofoli, L.F. Cabeça, I. Mazzaro, L.F. Fraceto, E. de Paula, J. Drug Target. 20, 85 (2012)CrossRefGoogle Scholar
  48. 48.
    L.M.A. Pinto, M.B. de Jesus, E. de Paula E, A.C.S. Lino, J.B. Alderete, H.A. Duarte, Y. Takahata, J. Molec. Struc. (Theochem) 678, 63 (2004)CrossRefGoogle Scholar
  49. 49.
    L.F. Cabeça, I.M. Figueiredo, E. de Paulab, A.J. Marsaiolia, Magn. Reson. Chem. 49, 295 (2011)CrossRefGoogle Scholar
  50. 50.
    J.J. Thomas, H.M. Jennings, A.J. Allen, J. Phys. Chem. C 114, 7594 (2010)CrossRefGoogle Scholar
  51. 51.
    A. Benetti, J. Jacobsen, M.T.F. Telling, V. Garcia-Sakai, H.N. Bordallo, ISIS Neutron and Muon Source Annual Review 2013 (RAL Library, Didcot, 2013)Google Scholar

Copyright information

© EDP Sciences and Springer 2014

Authors and Affiliations

  • J. Fischer
    • 1
  • N. Tsapatsaris
    • 2
    • 3
  • E. de Paula
    • 4
  • H. N. Bordallo
    • 2
    • 3
  1. 1.Forschungszentrum JulichJulichGermany
  2. 2.The Niels Bohr InstituteUniversity of CopenhagenCopenhagenDenmark
  3. 3.European Spallation Source ESS ABLundSweden
  4. 4.Department of Biochemistry State University of Campinas (UNICAMP)CampinasBrazil

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