The European Physical Journal Special Topics

, Volume 222, Issue 10, pp 2705–2712 | Cite as

Wavelet-analysis of gastric microcirculation in rats with ulcer bleedings

  • A.N. PavlovEmail author
  • O.V. Semyachkina-Glushkovskaya
  • O.N. Pavlova
  • O.A. Bibikova
  • J. Kurths
Regular Article Applications in Biology and Medicine


Nitric oxide (NO) plays an important role in regulation of central and peripheral circulation in normal state and during hemorrhagic stress. Because the impaired gastric mucosal blood flow is the major cause of gastroduodenal lesions including ulcer bleeding (UB), we study in this work the NO-ergic mechanism responsible for regulation of this blood flow. Our study is performed in rats with a model of stress-induced UB using laser Doppler flowmetry (LDF) that characterizes the rate of blood flow by measuring a Doppler shift of the laser beam scattered by the moving red blood cells. Numerical analysis of LDF-data is based on the discrete wavelet-transform (DWT) using Daubechies wavelets aiming to quantify influences of NO on the gastric microcirculation. We show that the stress-induced UB is associated with an increased level of NO in the gastric tissue and a stronger vascular sensitivity to pharmacological modulation of NO-production by L-NAME. We demonstrate that wavelet-based analyses of NO-dependent regulation of gastric microcirculation can provide an effective endoscopic diagnostics of a risk of UB.


Nitric Oxide European Physical Journal Special Topic Laser Doppler Flowmetry Daubechies Wavelet Gastric Mucosal Blood Flow 
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Copyright information

© EDP Sciences and Springer 2013

Authors and Affiliations

  • A.N. Pavlov
    • 1
    Email author
  • O.V. Semyachkina-Glushkovskaya
    • 2
  • O.N. Pavlova
    • 1
  • O.A. Bibikova
    • 2
  • J. Kurths
    • 3
    • 4
  1. 1.Physics Department, Saratov State UniversitySaratovRussia
  2. 2.Biology Department, Saratov State UniversitySaratovRussia
  3. 3.Physics Department, Humboldt UniversityBerlinGermany
  4. 4.Potsdam Institute for Climate Impact ResearchPotsdamGermany

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