Advertisement

The European Physical Journal Special Topics

, Volume 222, Issue 10, pp 2705–2712 | Cite as

Wavelet-analysis of gastric microcirculation in rats with ulcer bleedings

  • A.N. PavlovEmail author
  • O.V. Semyachkina-Glushkovskaya
  • O.N. Pavlova
  • O.A. Bibikova
  • J. Kurths
Regular Article Applications in Biology and Medicine

Abstract

Nitric oxide (NO) plays an important role in regulation of central and peripheral circulation in normal state and during hemorrhagic stress. Because the impaired gastric mucosal blood flow is the major cause of gastroduodenal lesions including ulcer bleeding (UB), we study in this work the NO-ergic mechanism responsible for regulation of this blood flow. Our study is performed in rats with a model of stress-induced UB using laser Doppler flowmetry (LDF) that characterizes the rate of blood flow by measuring a Doppler shift of the laser beam scattered by the moving red blood cells. Numerical analysis of LDF-data is based on the discrete wavelet-transform (DWT) using Daubechies wavelets aiming to quantify influences of NO on the gastric microcirculation. We show that the stress-induced UB is associated with an increased level of NO in the gastric tissue and a stronger vascular sensitivity to pharmacological modulation of NO-production by L-NAME. We demonstrate that wavelet-based analyses of NO-dependent regulation of gastric microcirculation can provide an effective endoscopic diagnostics of a risk of UB.

Keywords

Nitric Oxide European Physical Journal Special Topic Laser Doppler Flowmetry Daubechies Wavelet Gastric Mucosal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S.V. Kapralov, Y.G. Shapkin, V.V. Lychagov, V.V. Tuchin, Proc. SPIE 6535, 653519 (2007)CrossRefGoogle Scholar
  2. 2.
    C. Szabo, T. Billiar, Shock 12, 1 (1999)CrossRefGoogle Scholar
  3. 3.
    J. Collins, Y. Vodovotz, C. Hierholzer, R. Villavicencio, S. Liu, S. Alber, D. Gallo, D. Stolz, C. Watkins, A. Godfrey, W. Gooding, E. Kelly, A. Peitzman, T. Billiar, Shock 19, 117 (2003)CrossRefGoogle Scholar
  4. 4.
    D. Landry, J. Oliver, J. Clin. Invest. 89, 2071 (1992)CrossRefGoogle Scholar
  5. 5.
    J. Preiser, H. Zhang, F. Debelle, P. Fesler, S.A. Kafi, R. Naeije, J. Vincent, Shock 19, 223 (2003)CrossRefGoogle Scholar
  6. 6.
    J. Brayden, Clin. Exp. Pharmacol. Physiol. 29, 312 (2002)CrossRefGoogle Scholar
  7. 7.
    M. Nelson, J. Quayle, Am. J. Physiol. 268, 799 (1995)Google Scholar
  8. 8.
    Y. Meyer (ed.), Wavelets and Applications (Springer-Verlag, 1992)Google Scholar
  9. 9.
    A. Aldroubi, M. Unser (eds.), Wavelets in medicine and biology (CRC Press, 1996)Google Scholar
  10. 10.
    P.S. Addison, The Illustrated Wavelet Transform Handbook: Applications in Science, Engineering, medicine and Finance (IOP Publishing, 2002)Google Scholar
  11. 11.
    O.V. Sosnovtseva, A.N. Pavlov, N.A. Brazhe, A.R. Brazhe, L.A. Erokhova, G.V. Maksimov, E. Mosekilde, Phys. Rev. Lett. 94, 218103 (2005)ADSCrossRefGoogle Scholar
  12. 12.
    S. Thurner, M.C. Feurstein, M.C. Teich, Phys. Rev. Lett. 80, 1544 (1998)ADSCrossRefGoogle Scholar
  13. 13.
    A.N. Pavlov, V.S. Anishchenko, Physics-Uspekhi 50, 819 (2007)ADSCrossRefGoogle Scholar
  14. 14.
    D.J. Marsh, O.V. Sosnovtseva, A.N. Pavlov, K.-P . Yip, N.-H. Holstein-Rathlou, Am. J. Physiol. 288, R1160 (2005)Google Scholar
  15. 15.
    A.N. Pavlov, V.A. Makarov, E. Mosekilde, O.V. Sosnovtseva, Briefings Bioinformatics 7, 375 (2006)CrossRefGoogle Scholar
  16. 16.
    O.V. Sosnovtseva, A.N. Pavlov, E. Mosekilde, K.-P. Yip, N.-H. Holstein-Rathlou, D.J. Marsh, Am. J. Physiol. 293, F1545 (2007)Google Scholar
  17. 17.
    A.N. Pavlov, A.A. Anisimov, O.V. Semyachkina-Glushkovskaya, E.G. Matasova, J. Kurths, Physiol. Meas. 30, 707 (2009)CrossRefGoogle Scholar
  18. 18.
    J. Sun, X. Zhang, M. Broderick, H. Fein, Assay Sensors 3, 276 (2003)CrossRefGoogle Scholar
  19. 19.
    I. Daubechies, Ten Lectures on Wavelets (SIAM, 1992)Google Scholar
  20. 20.
    W.H. Press, B.P. Flannery, S.A. Teukolsky, W.T. Vetterling, Numerical recipes in C: The Art of Scientific Computing 2nd edn. (Cambridge, 1992)Google Scholar
  21. 21.
    V.A. Makarov, A.N. Pavlov, A.N. Tupitsyn, Proc. SPIE 6855, 68550M (2008)ADSCrossRefGoogle Scholar
  22. 22.
    H.M. Stauss, Am. J. Physiol. 292, R902 (2007)Google Scholar
  23. 23.
    H.M. Stauss, Clin. Exp. Pharmacol. Physiol. 34, 362 (2007)CrossRefGoogle Scholar

Copyright information

© EDP Sciences and Springer 2013

Authors and Affiliations

  • A.N. Pavlov
    • 1
    Email author
  • O.V. Semyachkina-Glushkovskaya
    • 2
  • O.N. Pavlova
    • 1
  • O.A. Bibikova
    • 2
  • J. Kurths
    • 3
    • 4
  1. 1.Physics Department, Saratov State UniversitySaratovRussia
  2. 2.Biology Department, Saratov State UniversitySaratovRussia
  3. 3.Physics Department, Humboldt UniversityBerlinGermany
  4. 4.Potsdam Institute for Climate Impact ResearchPotsdamGermany

Personalised recommendations