Wavelet-analysis of gastric microcirculation in rats with ulcer bleedings

The European Physical Journal Special Topics volume 222, pages 2705–2712 (2013)Cite this article

Abstract

Nitric oxide (NO) plays an important role in regulation of central and peripheral circulation in normal state and during hemorrhagic stress. Because the impaired gastric mucosal blood flow is the major cause of gastroduodenal lesions including ulcer bleeding (UB), we study in this work the NO-ergic mechanism responsible for regulation of this blood flow. Our study is performed in rats with a model of stress-induced UB using laser Doppler flowmetry (LDF) that characterizes the rate of blood flow by measuring a Doppler shift of the laser beam scattered by the moving red blood cells. Numerical analysis of LDF-data is based on the discrete wavelet-transform (DWT) using Daubechies wavelets aiming to quantify influences of NO on the gastric microcirculation. We show that the stress-induced UB is associated with an increased level of NO in the gastric tissue and a stronger vascular sensitivity to pharmacological modulation of NO-production by L-NAME. We demonstrate that wavelet-based analyses of NO-dependent regulation of gastric microcirculation can provide an effective endoscopic diagnostics of a risk of UB.

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References

  1. 1.

    S.V. Kapralov, Y.G. Shapkin, V.V. Lychagov, V.V. Tuchin, Proc. SPIE 6535, 653519 (2007)

    Article  Google Scholar 

  2. 2.

    C. Szabo, T. Billiar, Shock 12, 1 (1999)

    Article  Google Scholar 

  3. 3.

    J. Collins, Y. Vodovotz, C. Hierholzer, R. Villavicencio, S. Liu, S. Alber, D. Gallo, D. Stolz, C. Watkins, A. Godfrey, W. Gooding, E. Kelly, A. Peitzman, T. Billiar, Shock 19, 117 (2003)

    Article  Google Scholar 

  4. 4.

    D. Landry, J. Oliver, J. Clin. Invest. 89, 2071 (1992)

    Article  Google Scholar 

  5. 5.

    J. Preiser, H. Zhang, F. Debelle, P. Fesler, S.A. Kafi, R. Naeije, J. Vincent, Shock 19, 223 (2003)

    Article  Google Scholar 

  6. 6.

    J. Brayden, Clin. Exp. Pharmacol. Physiol. 29, 312 (2002)

    Article  Google Scholar 

  7. 7.

    M. Nelson, J. Quayle, Am. J. Physiol. 268, 799 (1995)

    Google Scholar 

  8. 8.

    Y. Meyer (ed.), Wavelets and Applications (Springer-Verlag, 1992)

  9. 9.

    A. Aldroubi, M. Unser (eds.), Wavelets in medicine and biology (CRC Press, 1996)

  10. 10.

    P.S. Addison, The Illustrated Wavelet Transform Handbook: Applications in Science, Engineering, medicine and Finance (IOP Publishing, 2002)

  11. 11.

    O.V. Sosnovtseva, A.N. Pavlov, N.A. Brazhe, A.R. Brazhe, L.A. Erokhova, G.V. Maksimov, E. Mosekilde, Phys. Rev. Lett. 94, 218103 (2005)

    ADS  Article  Google Scholar 

  12. 12.

    S. Thurner, M.C. Feurstein, M.C. Teich, Phys. Rev. Lett. 80, 1544 (1998)

    ADS  Article  Google Scholar 

  13. 13.

    A.N. Pavlov, V.S. Anishchenko, Physics-Uspekhi 50, 819 (2007)

    ADS  Article  Google Scholar 

  14. 14.

    D.J. Marsh, O.V. Sosnovtseva, A.N. Pavlov, K.-P . Yip, N.-H. Holstein-Rathlou, Am. J. Physiol. 288, R1160 (2005)

    Google Scholar 

  15. 15.

    A.N. Pavlov, V.A. Makarov, E. Mosekilde, O.V. Sosnovtseva, Briefings Bioinformatics 7, 375 (2006)

    Article  Google Scholar 

  16. 16.

    O.V. Sosnovtseva, A.N. Pavlov, E. Mosekilde, K.-P. Yip, N.-H. Holstein-Rathlou, D.J. Marsh, Am. J. Physiol. 293, F1545 (2007)

    Google Scholar 

  17. 17.

    A.N. Pavlov, A.A. Anisimov, O.V. Semyachkina-Glushkovskaya, E.G. Matasova, J. Kurths, Physiol. Meas. 30, 707 (2009)

    Article  Google Scholar 

  18. 18.

    J. Sun, X. Zhang, M. Broderick, H. Fein, Assay Sensors 3, 276 (2003)

    Article  Google Scholar 

  19. 19.

    I. Daubechies, Ten Lectures on Wavelets (SIAM, 1992)

  20. 20.

    W.H. Press, B.P. Flannery, S.A. Teukolsky, W.T. Vetterling, Numerical recipes in C: The Art of Scientific Computing 2nd edn. (Cambridge, 1992)

  21. 21.

    V.A. Makarov, A.N. Pavlov, A.N. Tupitsyn, Proc. SPIE 6855, 68550M (2008)

    ADS  Article  Google Scholar 

  22. 22.

    H.M. Stauss, Am. J. Physiol. 292, R902 (2007)

    Google Scholar 

  23. 23.

    H.M. Stauss, Clin. Exp. Pharmacol. Physiol. 34, 362 (2007)

    Article  Google Scholar 

Download references

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Affiliations

  1. Physics Department, Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia

    A.N. Pavlov & O.N. Pavlova

  2. Biology Department, Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia

    O.V. Semyachkina-Glushkovskaya & O.A. Bibikova

  3. Physics Department, Humboldt University, Newtonstrasse 15, 12489, Berlin, Germany

    J. Kurths

  4. Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473, Potsdam, Germany

    J. Kurths

Authors
  1. A.N. Pavlov
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  2. O.V. Semyachkina-Glushkovskaya
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  3. O.N. Pavlova
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  4. O.A. Bibikova
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  5. J. Kurths
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Correspondence to A.N. Pavlov.

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Pavlov, A., Semyachkina-Glushkovskaya, O., Pavlova, O. et al. Wavelet-analysis of gastric microcirculation in rats with ulcer bleedings. Eur. Phys. J. Spec. Top. 222, 2705–2712 (2013). https://doi.org/10.1140/epjst/e2013-02050-7

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Keywords

  • Nitric Oxide
  • European Physical Journal Special Topic
  • Laser Doppler Flowmetry
  • Daubechies Wavelet
  • Gastric Mucosal Blood Flow