The European Physical Journal Special Topics

, Volume 222, Issue 10, pp 2697–2704 | Cite as

Modelling of photo-thermal control of biological cellular oscillators

  • G.S. Assanov
  • Z.Zh. Zhanabaev
  • A.O. Govorov
  • A.B. NeimanEmail author
Regular Article Applications in Biology and Medicine


We study the transient dynamics of biological oscillators subjected to brief heat pulses. A prospective well-defined experimental system for thermal control of oscillators is the peripheral electroreceptors in paddlefish. Epithelial cells in these receptors show spontaneous voltage oscillations which are known to be temperature sensitive. We use a computational model to predict the effect of brief thermal pulses in this system. In our model thermal stimulation is realized through the light excitation of gold nanoparticles delivered in close proximity to epithelial cells and generating heat due to plasmon resonance. We use an ensemble of modified Morris-Lecar systems to model oscillatory epithelial cells. First, we validate that the model quantitatively reproduces the dynamics of epithelial oscillations in paddlefish electroreceptors, including responses to static and slow temperature changes. Second, we use the model to predict transient responses to short heat pulses generated by the light actuated gold nanoparticles. The model predicts that the epithelial oscillators can be partially synchronized by brief 5–15 ms light stimuli resulting in a large-amplitude oscillations of the mean field potential.


European Physical Journal Special Topic Instantaneous Frequency Heat Pulse Phase Reset Sensory Hair Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© EDP Sciences and Springer 2013

Authors and Affiliations

  • G.S. Assanov
    • 1
  • Z.Zh. Zhanabaev
    • 1
  • A.O. Govorov
    • 2
  • A.B. Neiman
    • 2
    Email author
  1. 1.Al-Farabi Kazakh National UniversityAlmatyKazakhstan
  2. 2.Department of Physics and AstronomyOhio UniversityAthensUSA

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