The European Physical Journal Special Topics

, Volume 191, Issue 1, pp 147–158 | Cite as

Filament capping and nucleation in actin-based motility

  • M. FaberEmail author
  • M. Enculescu
  • M. Falcke
Regular article


Propulsion by actin polymerization is versatilely used in cell motility. Here, we investigate a model of the semi-flexible region of an actin gel close to a propelled object describing the force generation, the dynamics of the propagation velocity, filament attachment to and detachment from the obstacle surface and dynamics of the number of filaments, which result from filament nucleation and capping. The model equations are derived as moment equations of the length distributions. We find a variety of dynamic regimes. The filament number may respond very sensitively to small changes of the attachment rate.


European Physical Journal Special Topic Lipid Vesicle Dynamic Regime Moment Equation Contour Length 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© EDP Sciences and Springer 2011

Authors and Affiliations

  1. 1.Mathematical Cell Physiology, Max Delbrück Center for Molecular MedicineBerlinGermany
  2. 2.Institute for Theoretical Physics, Technische UniversitätBerlinGermany

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