The European Physical Journal Special Topics

, Volume 154, Issue 1, pp 285–288 | Cite as

The effect of 4-hydroxycoumarin and umbelliferone on DPPC bilayers. Ultrasound study

  • K. Wojtowicz


The organisation of two coumarins, 4-hydroxycoumarin and 7-hydroxy- coumarin (umbelliferone) in dipalmitolyphosphatidylcholine (DPPC) was examined in the study. Ultrasound absorption technique was applied to study the effect of the presence in DPPC membranes of one of the coumarines on the parameters of phase transition. 4-hydroxycoumarin was found to change both phase transition temperature of this transition, and cooperativity more than umbelliferone. Different influence of these examined compounds is associated with their different location in the DPPC membrane, what results from different distribution of amphyphilness in molecules of both compounds.


Coumarin European Physical Journal Special Topic DPPC Acyl Chain Phase Transition Temperature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. J.S. Lopez-Gonzalez, H. Prado-Garcia, D. Aquilar-Cazares, J.A. Molina-Guarneros, J. Morales-Fuentes, J. Manioki, Lung Cancer 43, 275 (2004) Google Scholar
  2. B. Ramesh, K.V. Pugalendi, Yale J. Biol. Med. 78, 189 (2005) Google Scholar
  3. D.J. Fort, E.L. Stover, T. Propst, M.A. Hull, J.A. Bantle, Drug. Chem. Toxicol. 21, 15 (1998) Google Scholar
  4. J.C. Jung, J.H. Lee, S. Oh, J.G. Lee, O.S. Park, Bioorg. Med. Chem. Lett. 14, 5527 (2004) Google Scholar
  5. R.P.D.II Morse, L.D. Ma, R.L. Magin, F. Dunn, Chem. Phys. Lipids 103, 1 (1999) Google Scholar
  6. F. Eggers, Th. Funck, Naturwissenschaften 63, 280 (1976) Google Scholar
  7. K.Wojtowicz, Inst. Sci. Techn. 27, 290 (1999) Google Scholar
  8. S. Biswas, S.C. Bhattacharya, B.B. Bhowmik, S.P. Moulik, J. Coll. Interface Sci. 244, 145 (2001) Google Scholar
  9. M. Gawlikowski, T. Pustelny, R. Kustosz, J. Phys. IV (France) 137, 73 (2006) Google Scholar
  10. K. Wojtowicz, to be published in Annales UMCS section DDD Google Scholar

Copyright information

© EDP Sciences/Società Italiana di Fisica/Springer-Verlag 2008

Authors and Affiliations

  • K. Wojtowicz
    • 1
  1. 1.Department of BiophysicsMedical University of LublinLublinPoland

Personalised recommendations