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The role of pressure in cancer growth

  • Alessandro Taloni
  • Martine Ben Amar
  • Stefano Zapperi
  • Caterina A.M. La Porta
Review
Part of the following topical collections:
  1. Focus Point on the Physics of Cancer

Abstract.

The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenvironment is an important issue still to be fully explored. In order to grow, tumors have to overcome the mechanical resistance posed by the tissues in which they originate, while cancer cells involved in metastasis are often subject to fluid pressure. Here we review the recent literature describing the role of solid and fluid pressure on tumor growth and progression. We discuss a variety of in vitro experiments as well as computational models used to interpret them. We conclude discussing future perspectives.

Keywords

Melanoma Osmotic Pressure Tumor Spheroid Solid Stress External Mechanical Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Società Italiana di Fisica and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Alessandro Taloni
    • 1
    • 2
    • 3
  • Martine Ben Amar
    • 4
    • 5
  • Stefano Zapperi
    • 1
    • 2
    • 3
    • 6
    • 7
  • Caterina A.M. La Porta
    • 1
    • 8
  1. 1.Center for Complexity & BiosystemsUniversity of MilanMilanItaly
  2. 2.Department of PhysicsUniversity of MilanMilanItaly
  3. 3.Institute for Scientific Interchange FoundationTurinItaly
  4. 4.Laboratoire de Physique Statistique, Ecole Normale SupérieureUPMC Univ. Paris 06ParisFrance
  5. 5.Institut Universitaire de Cancérologie, Faculté de médecineUniversité Pierre et Marie-Curie Paris 6ParisFrance
  6. 6.CNR - IENIMilanItaly
  7. 7.Department of Applied PhysicsAalto UniversityEspooFinland
  8. 8.Department of BioscienceUniversity of MilanMilanItaly

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