Neurodegenerative dementias: From MR Physics lab to assessment room

  • S. D. BrunoEmail author
  • M. Cercignani
  • C. A. M. Wheeler-Kingshott
Part of the following topical collections:
  1. Focus Point on Advanced Physical Methods in Brain Research


Theimpact of neuroimaging on the study and understanding of dementing illnesses has been enormous. Here we review the main MR structural technical developments applied to Alzheimer’s disease and fronto-temporal dementia, two forms of neurodegenerative disorders that have a number of similarities but also several differences. The possibility of detecting increasingly subtle brain changes, together with the need of handling larger and larger data sets, keeping up with the ever expanding aging population, are perhaps the main driving forces behind recent MR technique developments in the field of dementia. The measurement of atrophy is now integrated by more advanced approaches, investigating the alterations of the architecture of brain tissues beyond pure volumetric loss. Brain connectivity is now studied in vivo with techniques such as diffusion tensor imaging and tractography. Also, automated methods of subject classification open up new possibilities of rapid and cost-effective diagnosis. The inter-disciplinary efforts are changing the clinical scenario of dementia care from one of helpless defeat to one of promising innovation.


Dementia White Matter Grey Matter Mild Cognitive Impairment Fractional Anisotropy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Società Italiana di Fisica and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • S. D. Bruno
    • 1
    Email author
  • M. Cercignani
    • 2
  • C. A. M. Wheeler-Kingshott
    • 3
  1. 1.Centro Malattie NeurodegenerativeAzienda Ospedaliera “Card. G. Panico”TricaseItaly
  2. 2.Clinical Imaging Science Centre, Brighton and Sussex Medical SchoolUniversity of SussexBrightonUK
  3. 3.Department of NeuroinflammationUCL, Institute of NeurologyLondonUK

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