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Alzheimer’s disease markers from structural MRI and FDG-PET brain images

  • Andrea ChincariniEmail author
  • Paolo Bosco
  • Gianluca Gemme
  • Silvia Morbelli
  • Dario Arnaldi
  • Francesco Sensi
  • Ilaria Solano
  • Nicola Amoroso
  • Sabina Tangaro
  • Renata Longo
  • Sandro Squarcia
  • Flavio Nobili
Regular Article
Part of the following topical collections:
  1. Focus Point on Advanced Physical Methods in Brain Research

Abstract

Despite the widespread use of neuroimaging tools (morphological and functional) in the routine diagnostic of cerebral diseases, the information available by the end user -the clinician- remains largely limited to qualitative visual analysis. This restriction greatly reduces the diagnostic impact of neuroimaging in routine clinical practice and increases the risk of misdiagnosis. In this context, researches are focussing on the development of sophisticated automatic analyses able to extract clinically relevant information from the captured data. The identification of biological markers at early stages of Alzheimer’s disease (AD) contributes to diagnostic accuracy and adds prognostic value. However, in spite of recent developments, results of structural and functional imaging studies on predicting conversion to AD are not uniform. We provide here an overview of analysis methods and approaches, discussing their contribution to clinical assessment.

Keywords

Mild Cognitive Impairment Default Mode Network Mild Cognitive Impairment Patient Structural Magnetic Resonance Imaging Mild Cognitive Impairment Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Società Italiana di Fisica and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Andrea Chincarini
    • 1
    Email author
  • Paolo Bosco
    • 1
    • 3
  • Gianluca Gemme
    • 1
  • Silvia Morbelli
    • 2
  • Dario Arnaldi
    • 7
  • Francesco Sensi
    • 1
  • Ilaria Solano
    • 1
    • 3
  • Nicola Amoroso
    • 4
  • Sabina Tangaro
    • 4
  • Renata Longo
    • 5
    • 6
  • Sandro Squarcia
    • 1
    • 3
  • Flavio Nobili
    • 7
  1. 1.INFNSezione di GenovaGenovaItaly
  2. 2.Medicina NucleareDip. di Medicina Interna e Specialità Mediche Università degli Studi di GenovaGenovaItaly
  3. 3.Dipartimento di FisicaUniversità degli Studi di GenovaGenovaItaly
  4. 4.Dipartimento Interateneo di Fisica “M. Merlin” and TIRESUniversità degli Studi di BariBariItaly
  5. 5.INFNSezione di TriesteTriesteItaly
  6. 6.Dipartimento di FisicaUniversità degli Studi di TriesteTriesteItaly
  7. 7.Neurofisiologia Clinica, Dipartimento di Neuroscienze, Oftalmologia e GeneticaAzienda Ospedale-Università S. Martino, GenovaGenovaItaly

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