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Treatment planning in proton therapy

  • M. SchwarzEmail author
Review
Part of the following topical collections:
  1. Focus Point on Hadrontherapy in Europe

Abstract

Radiotherapy treatment planning is a procedure that, using radiation beam and patient’s anatomy models as input data, produces as output the machine instructions to deliver the treatment and the expected dose distribution in the patient. Now that most proton therapy centers are moving from double scattered proton beams to active delivery systems such as pencil beam scanning (PBS), there is a need for treatment planning tools that could generate safe and effective dose distribution by taking full benefit of the potential of PBS degrees of freedom, and by avoiding the risks associated to this modality. The paper provides an overview of the current status of proton treatment planning techniques, from the creation of a patient model via imaging, to dose calculation, to the optimization of plans using intensity modulated proton therapy (IMPT). The issue of plan sensitivity to input data (“plan robustness”) is emphasized and current approaches to robust optimization are presented. Finally, current developments in “adaptive planning” and in the plan design for moving organs are shortly discussed.

Keywords

Planning Target Volume Dose Distribution Robust Optimization Linear Energy Transfer Range Uncertainty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Jikun Wei, George A. Sandison, Wen-Chien Hsi, Michael Ringor, Xiaoyi Lu, Phys. Med. Biol. 51, 5183 (2006).CrossRefGoogle Scholar
  2. 2.
    C.S. Olive, M.R. Kaus, V. Pekar, K. Eck, L. Spies, Segmentation- aided adaptive filtering for metal artifacts reduction in radio-therapeutic ct images, in Proceeding of SPIE, vol. 5370 (2004) pp. 1991--2002Google Scholar
  3. 3.
    M. Bal, L. Spies, Med. Phys. 33, 2852 (2006).CrossRefGoogle Scholar
  4. 4.
    U. Schneider, E. Pedroni, A. Lomax, Phys. Med. Biol. 41, 111 (1996).CrossRefGoogle Scholar
  5. 5.
    H. Jiang, J. Seco, H. Paganetti, Med. Phys. 34, 1439 (2007).CrossRefGoogle Scholar
  6. 6.
    L. Hong, M. Goitein, M. Bucciolini, R. Comiskey, B. Gottschalk, S. Rosenthal, C. Serago, M. Urie, Phys. Med. Biol. 41, 1305 (1996).CrossRefGoogle Scholar
  7. 7.
    E. Pedroni, S. Scheib, T. Böhringer, A. Coray, M. Grossmann, S. Lin, A. Lomax, Phys. Med. Biol. 50, 541 (2005).CrossRefGoogle Scholar
  8. 8.
    M. Soukup, M. Fippel, M. Alber, Phys. Med. Biol. 50, 5089 (2005).CrossRefGoogle Scholar
  9. 9.
    B. Schaffner, E. Pedroni, A. Lomax, Phys. Med. Biol. 44, 27 (1999).CrossRefGoogle Scholar
  10. 10.
    T. Bortfeld, Med. Phys. 24, 2024 (1997).CrossRefGoogle Scholar
  11. 11.
    M. Fippel, M. Soukup, Med. Phys. 31, 2263 (2004).CrossRefGoogle Scholar
  12. 12.
    H. Paganetti, H. Jiang, S.-Y. Lee, H.M. Kooy, Med. Phys. 31, 2107 (2004).CrossRefGoogle Scholar
  13. 13.
    A. Tourovsky, A.J. Lomax, U. Schneider, E. Pedroni, Phys. Med. Biol. 50, 971 (2005).CrossRefGoogle Scholar
  14. 14.
    Xun Jia, Xuejun Gu, Josep Sempau, Dongju Choi, Amitava Majumdar, Steve B. Jiang, Phys. Med. Biol. 55, 3077 (2010).CrossRefGoogle Scholar
  15. 15.
    A. Badal, A. Badano, Med. Phys. 36, 4878 (2009).CrossRefGoogle Scholar
  16. 16.
    M. Urie, M. Goitein, M. Wagner, Phys. Med. Biol. 29, 553 (1984).CrossRefGoogle Scholar
  17. 17.
    M.F. Moyers, D.W. Miller, D.A. Bush, J.D. Slater, Int. J. Radiat. Oncol. Biol. Phys. 49, 1429 (2001).CrossRefGoogle Scholar
  18. 18.
    ICRU. Prescribing, recording and reporting photon beam therapy (ICRU report 50). ICRU report, pages 357--360, 1993Google Scholar
  19. 19.
    M. van Herk, Semin. Radiat. Oncol. 14, 52 (2004).CrossRefGoogle Scholar
  20. 20.
    M.H. Phillips, E. Pedroni, H. Blattman, T. Boehringer, A. Coray, S. Scheib, Phys. Med. Biol. 37, 223 (1992).CrossRefGoogle Scholar
  21. 21.
    T. Bortfeld, K. Jokivarsi, M. Goitein, J. Kung, S.B. Jiang, Phys. Med. Biol. 47, 2203 (2002).CrossRefGoogle Scholar
  22. 22.
    A. Lomax, Phys. Med. Biol. 44, 185 (1999).CrossRefGoogle Scholar
  23. 23.
    M.L. Kessler, D.L. McShan, M.A. Epelman, K.A. Vineberg, A. Eisbruch, T.S. Lawrence, B.A. Fraass, Opt. Eng. 6, 421 (2005).MathSciNetzbMATHCrossRefGoogle Scholar
  24. 24.
    A. Niemierko, Med. Phys. 26, 1100 (1999).Google Scholar
  25. 25.
    F. Albertini, E.B. Hug, A.J. Lomax, Phys. Med. Biol. 55, 2863 (2010).CrossRefGoogle Scholar
  26. 26.
    D. Pflugfelder, J.J. Wilkens, H. Szymanowski, U. Oelfke, Med. Phys. 34, 1506 (2007).CrossRefGoogle Scholar
  27. 27.
    J.C. Stroom, H.C. de Boer, H. Huizenga, A.G. Visser, Int. J. Radiat. Oncol. Biol. Phys. 43, 905 (1999).CrossRefGoogle Scholar
  28. 28.
    C. Baum, M. Alber, M. Birkner, F. Nusslin, Radiother. Oncol. 78, 27 (2006).CrossRefGoogle Scholar
  29. 29.
    Marnix G. Witte, Joris van der Geer, Christoph Schneider, Joos V. Lebesque, Markus Alber, Marcel van Herk, Med. Phys. 34, 3544 (2007).CrossRefGoogle Scholar
  30. 30.
    Jan Unkelbach, Thomas Bortfeld, Benjamin C. Martin, Martin Soukup, Med. Phys. 36, 149 (2009).CrossRefGoogle Scholar
  31. 31.
    D. Pflugfelder, J.J. Wilkens, U. Oelfke, Phys. Med. Biol. 53, 1689 (2008).CrossRefGoogle Scholar
  32. 32.
    A. Fredriksson, A. Forsgren, B. Hårdemark, Med. Phys. 38, 1672 (2011).CrossRefGoogle Scholar
  33. 33.
    Antony J. Lomax, Eros Pedroni, Hanspeter Rutz, Gudrun Goitein, Z. Med. Phys. 14, 147 (2004).Google Scholar
  34. 34.
    A.J. Lomax, Phys. Med. Biol. 53, 1027 (2008).CrossRefGoogle Scholar
  35. 35.
    M. Schwarz, J. der Geer, M. Van Herk, J.V. Lebesque, B.J. Mijnheer, E.M.F. Damen, Int. J. Radiat. Oncol. Biol. Phys. 65, 1260 (2006).CrossRefGoogle Scholar
  36. 36.
    Ursula Nestle, Wolfgang Weber, Michael Hentschel, Anca-Ligia Grosu, Phys. Med. Biol. 54, R1 (2009) PMID: 19060363CrossRefGoogle Scholar
  37. 37.
    D. Létourneau, J.W. Wong, M. Oldham, M. Gulam, L. Watt, D.A. Jaffray, J.H. Siewerdsen, A.A. Martinez, Radiother. Oncol. 75, 279 (2005).CrossRefGoogle Scholar
  38. 38.
    D. Yan, F. Vicini, J. Wong, A. Martinez, Phys. Med. Biol. 42, 123 (1997).CrossRefGoogle Scholar
  39. 39.
    C. Bert, N. Saito, A. Schmidt, N. Chaudhri, D. Schardt, E. Rietzel, Med. Phys. 34, 4768 (2007).CrossRefGoogle Scholar
  40. 40.
    S.M. Zenklusen, E. Pedroni, D. Meer, Phys. Med. Biol. 55, 5103 (2010).CrossRefGoogle Scholar
  41. 41.
    M. von Siebenthal, G. Székely, U. Gamper, P. Boesiger, A. Lomax, P. Cattin, Phys. Med. Biol. 52, 1547 (2007).CrossRefGoogle Scholar
  42. 42.
    Jan-Jakob Sonke, Joos Lebesque, Marcel van Herk, Int. J. Radiat. Oncol. Biol. Phys. 70, 590 (2008).CrossRefGoogle Scholar
  43. 43.
    ICRU. Prescribing, recording, and reporting proton beam therapy (ICRU report 78).Google Scholar
  44. 44.
    C. Grassberger, A. Trofimov, A. Lomax, H. Paganetti, Int. J. Radiat. Oncol. Biol. Phys. 80, 1559 (2011).CrossRefGoogle Scholar

Copyright information

© Società Italiana di Fisica and Springer 2011

Authors and Affiliations

  1. 1.Agenzia Provinciale per la ProtonterapiaTrentoItaly

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