Limiting diffusion coefficients of \(\alpha\),\(\omega\)-amino acids in water and in sodium chloride aqueous solutions at 298.15 K

  • Carmen M. Romero
  • Ginna P. Trujillo
  • Luis M. P. Verissimo
  • Miguel A. EstesoEmail author
  • M. Luísa Ramos
  • Ana C. F. RibeiroEmail author
Regular Article
Part of the following topical collections:
  1. Thermal Non-Equilibrium Phenomena in Soft Matter


Transport properties of model compounds in aqueous solutions such as amino acids can provide valuable information in order to understand the complex interactions in aqueous solutions as well as the protein stability in water and the relevant factors involved. Informations about the diffusion of amino acids in water and in aqueous solutions of sodium chloride are very scarce, especially for the 5-aminopentanoic acid and 6-aminohexanoic acid. In this study, limiting binary mutual diffusion coefficients at 298.15 K of 5-aminopentanoic and 6-aminohexanoic acids in aqueous solutions of NaCl 0.15 mol kg-1, using the Taylor dispersion technique, were determined and the results compared with the limiting binary mutual diffusion coefficients for 2-aminopentanoic acid, and 2-aminohexanoic acid, obtained in the same experimental conditions. The discussion of the properties of the selected amino acids is centered on the positions of the ionic groups in the hydrocarbon chain and, in addition, we have discussed the effects of NaCl on their structures and properties. The data on diffusion properties are supported by 1H, 13C and 23Na NMR experiments, which we have obtained for 5-aminopentanoic and 6-aminohexanoic acids, in aqueous solution, also in the presence of NaCl.

Graphical abstract


Topical issue: Thermal Non-Equilibrium Phenomena in Soft Matter 


  1. 1.
    R. Elango, R.O. Ball, P.B. Pencharz, Amino Acids 37, 19 (2009)CrossRefGoogle Scholar
  2. 2.
    P. Hardy, in Chemistry and Biochemistry of the Amino Acids, edited by G.C. Barrett (Chapman, Hall-Methuen, London, 1985)Google Scholar
  3. 3.
    E.J. Cohn, J.T. Edsall, Proteins, Amino Acids and Peptides as Ions and Dipolar Ions (Hafner Publishing Company, New York, 1965)Google Scholar
  4. 4.
    A.W. Hakin, M.M. Duke, J.L. Marty, K.E. Preuss, J. Chem. Soc. Faraday Trans. 90, 2027 (1994)CrossRefGoogle Scholar
  5. 5.
    T.V. Chalikian, A.P. Sarvazyan, K.J. Breslauer, J. Phys. Chem. 97, 13017 (1993)CrossRefGoogle Scholar
  6. 6.
    C.M. Romero, C.D. Oviedo, J. Solution Chem. 42, 1355 (2013)CrossRefGoogle Scholar
  7. 7.
    D.M. Rodríguez, C.M. Romero, J. Mol. Liq. 233, 487 (2017)CrossRefGoogle Scholar
  8. 8.
    C.M. Romero, M.A. Esteso, G.P. Trujillo, J. Chem. Eng. Data 63, 4012 (2018)CrossRefGoogle Scholar
  9. 9.
    H.J.V. Tyrrell, K.R. Harris, Diffusion in Liquids, second edition (Butterworths, London, 1984)Google Scholar
  10. 10.
    R. Callendar, D.G. Leaist, J. Solution Chem. 35, 353 (2006)CrossRefGoogle Scholar
  11. 11.
    B. Hunt, Int. J. Heat Mass Transfer 20, 393 (1976)CrossRefGoogle Scholar
  12. 12.
    D.M. Rodriguez, L.M.P. Verissimo, M.C.F. Barros, D.F.S.L. Rodrigues, M.M. Rodrigo, M.A. Esteso, C.M. Romero, A.C.F. Ribeiro, Eur. Phys. J. E 40, 21 (2017)CrossRefGoogle Scholar
  13. 13.
    T. Umecky, T. Kuga, T. Funazukuri, J. Chem. Eng. Data 51, 1705 (2006)CrossRefGoogle Scholar
  14. 14.
    Y. Ma, C. Zhu, P. Ma, K.T. Yu, J. Chem. Eng. Data 50, 1192 (2005)CrossRefGoogle Scholar
  15. 15.
    A.C.F. Ribeiro, M.M. Rodrigo, M.C.F. Barros, L.M.P. Veríssimo, C.M. Romero, A.J.M. Valente, M.A. Esteso, J. Chem. Thermodyn. 74, 133 (2014)CrossRefGoogle Scholar
  16. 16.
    M.M. Rodrigo, A.J.M. Valente, M.C.F. Barros, L.M.P. Veríssimo, C.M. Romero, M.A. Esteso, A.C.F. Ribeiro, J. Chem. Thermodyn. 74, 227 (2014)CrossRefGoogle Scholar
  17. 17.
    M.M. Rodrigo, M.A. Esteso, M.C.F. Barros, L.M.P. Verissimo, C.M. Romero, A.F. Suárez, M.L. Ramos, A.J.M. Valente, H.D. Burrows, A.C.F. Ribeiro, J. Chem. Thermodyn. 104, 110 (2017)CrossRefGoogle Scholar
  18. 18.
    E.S. Hamborg, W.P.M. Van Swaaij, G.F. Versteeg, J. Chem. Eng. Data 53, 1141 (2008)CrossRefGoogle Scholar
  19. 19.
    K. Yui, Y. Noda, M. Koido, M. Irie, I. Watanabe, T. Umecky, T. Funazukuri, J. Chem. Eng. Data 58, 2848 (2013)CrossRefGoogle Scholar
  20. 20.
    L.G. Longsworth, J. Am. Chem. Soc. 75, 5705 (1953)CrossRefGoogle Scholar
  21. 21.
    G. Taylor, Proc. R. Soc. London A 219, 186 (1953)ADSCrossRefGoogle Scholar
  22. 22.
    P.K. Glasoe, F.A. Long, J. Phys. Chem. 64, 188 (1960)CrossRefGoogle Scholar
  23. 23.
  24. 24.
    M.L. Ramos, L.L.G. Justino, A. Branco, C.M.G. Duarte, P.E. Abreu, S.M. Fonseca, H.D. Burrows, Dalton Trans. 40, 11732 (2011)CrossRefGoogle Scholar
  25. 25.
    M. Ramek, Struct. Chem. 6, 15 (1995)CrossRefGoogle Scholar
  26. 26.
    T. Umecky, K. Ehara, S. Omori, T. Kuga, K. Yui, T. Funazukuri, J. Chem. Eng. Data 58, 1909 (2013)CrossRefGoogle Scholar
  27. 27.
    D.G. Leaist, J. Solution Chem. 20, 175 (1991)CrossRefGoogle Scholar
  28. 28.
    D.G. Leaist, Electrochim. Acta 36, 309 (1991)CrossRefGoogle Scholar
  29. 29.
    M. Larrañaga, M.M. Bou-Ali, D. Soler, M. Martínez-Aguirre, A. Mialdun, V. Shevtsova, C.R. Mec. 341, 356 (2013)ADSCrossRefGoogle Scholar
  30. 30.
    A. Mialdun, J.C. Legros, V. Yasnou, V. Sechenyh, V. Shevtsova, Eur. Phys. J. E 38, 27 (2015)CrossRefGoogle Scholar
  31. 31.
    J.C. Legros, Y. Gaponenko, A. Mialdun, T. Triller, A. Hammon, C. Bauer, W. Köhler, V. Shevtsova, Phys. Chem. Chem. Phys. 17, 27713 (2015)CrossRefGoogle Scholar

Copyright information

© EDP Sciences, Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Carmen M. Romero
    • 1
  • Ginna P. Trujillo
    • 1
  • Luis M. P. Verissimo
    • 2
    • 3
  • Miguel A. Esteso
    • 3
    Email author
  • M. Luísa Ramos
    • 2
  • Ana C. F. Ribeiro
    • 2
    Email author
  1. 1.Departamento de Química, Facultad de CienciasUniversidad Nacional de Colombia Sede BogotáBogotá D.C.Colombia
  2. 2.Centro de Química and Department of ChemistryUniversity of CoimbraCoimbraPortugal
  3. 3.U.D. Química FísicaUniversidad de AlcaláAlcalá de Henares, MadridSpain

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