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The effect of gramicidin inclusions on the local order of membrane components

  • Elise Azar
  • Doru Constantin
  • Dror E. Warschawski
Regular Article

Abstract.

We study the local effect of the antimicrobial peptide Gramicidin A on bilayers composed of lipids or surfactants using nuclear magnetic resonance spectroscopy and wide-angle X-ray scattering, techniques that probe the orientational and positional order of the alkyl chains, respectively. The two types of order vary with temperature and peptide concentration in complex ways which depend on the membrane composition, highlighting the subtlety of the interaction between inclusions and the host bilayer. The amplitude of the variation is relatively low, indicating that the macroscopic constants used to describe the elasticity of the bilayer are unlikely to change with the addition of peptide.

Graphical abstract

Keywords

Living systems: Biological Matter 

Supplementary material

10189_2018_11644_MOESM1_ESM.pdf (431 kb)
The effect of gramicidin inclusions on the local order of membrane components

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Copyright information

© EDP Sciences, SIF, Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Elise Azar
    • 1
  • Doru Constantin
    • 1
  • Dror E. Warschawski
    • 2
    • 3
  1. 1.Laboratoire de Physique des Solides, CNRSUniv. Paris-Sud, Université Paris-SaclayOrsay CedexFrance
  2. 2.UMR 7099, CNRS-Université Paris Diderot, Institut de Biologie Physico-ChimiqueParisFrance
  3. 3.Département de ChimieUniversité du Québec à MontréalMontrealCanada

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