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Comparative study of non-invasive force and stress inference methods in tissue

  • S. IshiharaEmail author
  • K. Sugimura
  • S. J. Cox
  • I. Bonnet
  • Y. Bellaïche
  • F. Graner
Regular Article
Part of the following topical collections:
  1. Physical constraints of morphogenesis and evolution

Abstract

In the course of animal development, the shape of tissue emerges in part from mechanical and biochemical interactions between cells. Measuring stress in tissue is essential for studying morphogenesis and its physical constraints. For that purpose, a possible new approach is force inference (up to a single prefactor) from cell shapes and connectivity. It is non-invasive and can provide space-time maps of stress in a whole tissue, unlike existing methods. To validate this approach, three force-inference methods, which differ in their approach of treating indefiniteness in an inverse problem between cell shapes and forces, were compared. Tests using two artificial and two experimental data sets consistently indicate that our Bayesian force inference, by which cell-junction tensions and cell pressures are simultaneously estimated, performs best in terms of accuracy and robustness. Moreover, by measuring the stress anisotropy and relaxation, we cross-validated the force inference and the global annular ablation of tissue, each of which relies on different prefactors. A practical choice of force-inference methods in different systems of interest is discussed.

Graphical abstract

Keywords

Topical issue: Physical constraints of morphogenesis and evolution 

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Copyright information

© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • S. Ishihara
    • 1
    Email author
  • K. Sugimura
    • 2
    • 3
  • S. J. Cox
    • 4
  • I. Bonnet
    • 5
    • 6
  • Y. Bellaïche
    • 5
  • F. Graner
    • 5
    • 7
  1. 1.Graduate School of Arts and SciencesThe University of TokyoMeguro-ku, TokyoJapan
  2. 2.Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Kyoto UniversityKyotoJapan
  3. 3.RIKEN Brain Science InstituteWako, SaitamaJapan
  4. 4.Institute of Mathematics and PhysicsAberystwyth UniversityCeredigionUK
  5. 5.Genetics and Developmental Biology, Team “Polarity, division and morphogenesis”Institut Curie, UMR3215 CNRS, U934 InsermParisFrance
  6. 6.Physico-Chimie CurieInstitut Curie, UMR168 CNRS, UPMCParis Cedex 05France
  7. 7.Laboratoire Matière et Systèmes ComplexesUMR 7057 CNRS and Université Paris DiderotParis Cedex 13France

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